Cryptococcus laurentii as a new biocatalyst for the asymmetric reduction of substituted acetophenones was written by Kurbanoglu, Esabi B.;Zilbeyaz, Kani;Kurbanoglu, Namudar I.. And the article was included in Tetrahedron: Asymmetry in 2011.Quality Control of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:
Immobilized cells of the yeast Cryptococcus laurentii attached to calcium alginate have been introduced as a biocatalyst in the asym. reduction of substituted acetophenones. Forty isolates of microorganisms belonging to this taxonomical yeast group were isolated from various samples. Immobilized cells of these isolates were screened as reducing agents for acetophenone 1a to its corresponding alc. 1b. The four best isolates were selected and identified as Rhodotorula glutinis, Saccharomyces cerevisiae, Hansenula capsulata and C. laurentii by the VITEK 2 compact system. The use of the first three microorganisms is well known and therefore it was decided to explore C. laurentii as a new biocatalyst in organic reactions. The aim was to determine whether C. laurentii could be used to catalyze the bio-reduction of ketones to obtain the (R)- or (S)-isomer of the alc. with high enantiomeric purity. The isolate C. laurentii EBK-19 was selected for further experiments and studied in detail. More than 70% of the ketones tested were obtained with almost complete conversion (100%), while all the ketones tested were converted to the corresponding (S)-isomer-alcs. in up to > 99% enantiomeric excess (ee) under very mild reaction conditions. Amongst the chiral alcs. obtained, the enantiopure 1b obtained from the complete conversion of 1a using C. laurentii EBK-19 was produced on a large scale (9.3 g) using an immobilized cell reaction system. In conclusion, we have presented C. laurentii as a promising biocatalyst for the production of optically active phenylethanols. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Quality Control of (S)-1-(2-Fluorophenyl)ethanol).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of (S)-1-(2-Fluorophenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts