Ketene and its derivatives. II. Reaction of methylpyridine 1-oxide and methylquinoline 1-oxide with ketene was written by Kato, Tetsuzo;Goto, Yoshinobu;Yamamoto, Yutaka. And the article was included in Yakugaku Zasshi in 1962.SDS of cas: 1122-71-0 This article mentions the following:
Reaction of CH2:CO (produced from decomposition of Me2CO by a ketene generator) and 4-picoline 1-oxide and fractionation of the product gave 5% 4-pyridinemethanol, b15 117-18°, 0.3% 4-methyl-3-pyridinol, m. 117-20°, and 4% 4-picoline. Similarly, 2,6-lutidine 1-oxide yielded 33% 6-methyl-2-pyridinemethanol (picrate m. 132-4°), 17% 3-hydroxy-2,6-lutidine, m. 205-7°, and 4% 2,6-lutidine; 4-nitro-2,6-lutidine 1-oxide yielded 8% 4-nitro-6-methyl-2-pyridinemethanol, m. 118-19°, 2% 4-hydroxy-6-methyl-2-pyridinemethanol (HCl salt m. 225-7°), and 3% 4-nitro-2,6-lutidine [picrate, m. 194° (decomposition)]; quinaldine 1-oxide yielded 16% 2-quinolinemethanol, b4 145-60° (picrate, m. 154-6°), and α,α’-bis(2-quinolinemethanol), m. 215° (decomposition); lepidine 1-oxide yielded 4% 3-hydroxylepidine (picrate m. 209-10°). 3-Picoline 1-oxide, 4-nitropyridine 1-oxide, and 4-nitro-2-picoline 1-oxide gave no reaction product with CH2:CO. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0SDS of cas: 1122-71-0).
6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 1122-71-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts