2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of 2-(Trifluoromethyl)phenethyl alcohol
Peripherally acting enkephalin analogs. 2. Polar tri- and tetrapeptides was written by Hardy, George W.;Lowe, Lawrence A.;Mills, Gail;Sang, Pang Yih;Simpkin, Dean S. A.;Follenfant, Rhonda L.;Shankley, Clare;Smith, Terence W.. And the article was included in Journal of Medicinal Chemistry in 1989.Safety of 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:
The design, synthesis, and biol. activity of a series of D-Arg2-enkephalin-derived tetrapeptide amides and tripeptide aralkylamides are reported. These polar analogs were designed to be excluded from the central nervous system, with their action thus limited to peripheral opioid receptors. The effects of the nature of the aromatic ring, aryl ring substitution and aralkylamide chain length on activity were investigated; in a number of cases the N-terminal amino group of Tyr1 was converted to a guanidino group to further increase hydrophilicity. The peptides were all synthesized by classical solution methodol. The opioid activity of the peptides was assessed in vitro on the guinea pig ileum, and their antinociceptive activity was determined in vivo in chem. induced writhing models (peripheral activity) and in the hot-plate test (central activity) in rodents. The analgesic effects were predominantly mediated in the periphery, as demonstrated by antagonism of antinociception by the peripheral opioid antagonist N-methylnalorphine and by comparison of the activities in the writhing and hot-plate tests. As a class, the tetrapeptides were more potent than the tripeptides; Nα-amidination generally increased activity. A number of compounds exhibited very potent opioid activity and had the desired pharmacol. profile, indicating a high degree of peripheral selectivity. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Safety of 2-(Trifluoromethyl)phenethyl alcohol).
2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of 2-(Trifluoromethyl)phenethyl alcohol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts