1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C9H17NO3
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme was written by Hamilton, Matthew M.;Mseeh, Faika;McAfoos, Timothy J.;Leonard, Paul G.;Reyna, Naphtali J.;Harris, Angela L.;Xu, Alan;Han, Michelle;Soth, Michael J.;Czako, Barbara;Theroff, Jay P.;Mandal, Pijus K.;Burke, Jason P.;Virgin-Downey, Brett;Petrocchi, Alessia;Pfaffinger, Dana;Rogers, Norma E.;Parker, Connor A.;Yu, Simon S.;Jiang, Yongying;Krapp, Stephan;Lammens, Alfred;Trevitt, Graham;Tremblay, Martin R.;Mikule, Keith;Wilcoxen, Keith;Cross, Jason B.;Jones, Philip;Marszalek, Joseph R.;Lewis, Richard T.. And the article was included in Journal of Medicinal Chemistry in 2021.Electric Literature of C9H17NO3 This article mentions the following:
Indoleamine 2,3-dioxygenase 1 (IDO1), a heme-containing enzyme that mediates the rate-limiting step in the metabolism of L-tryptophan to kynurenine, has been widely explored as a potential immunotherapeutic target in oncol. The authors have developed a class of inhibitors with a conformationally constrained bicyclo[3.1.0]hexane core. These potently inhibited IDO1 in a cellular context by binding to the apoenzyme, as elucidated by biochem. characterization and X-ray crystallog. A SKOV3 tumor model was instrumental in differentiating compounds, leading to the identification of I (IACS-9779) and II (IACS-70465). IACS-70465 has excellent cellular potency, a robust pharmacodynamic response, and in a human whole blood assay was more potent than linrodostat (BMS-986205). IACS-9779 with a predicted human efficacious once-daily dose below 1 mg/kg to sustain >90% inhibition of IDO1 displayed an acceptable safety margin in rodent toxicol. and dog cardiovascular studies to support advancement into preclin. safety evaluation for human development. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3Electric Literature of C9H17NO3).
1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C9H17NO3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts