The efficacy of the adjunct use of subgingival air-polishing therapy with erythritol powder compared to conventional debridement alone during initial non-surgical periodontal therapy was written by Divnic-Resnik, Tihana;Pradhan, Harold;Spahr, Axel. And the article was included in Journal of Clinical Periodontology in 2022.Application In Synthesis of (2R,3S)-rel-Butane-1,2,3,4-tetraol This article mentions the following:
Aim : To assess the efficacy of the adjunct use of a subgingival erythritol powder air-polishing device (EPAP) in comparison to conventional subgingival instrumentation alone during initial non-surgical periodontal therapy. Materials and Methods : Twenty-one patients with generalized Stages 2 and 3 grade B periodontitis were included in this single center, single blinded, split-mouth, randomized clin. trial. Teeth on the control side were treated with conventional hand and ultrasonic instrumentation, while those on the contralateral test side was treated using EPAP as adjunct to conventional subgingival instrumentation with hand and ultrasonic instruments. Three months after initial instrumentation, persisting pockets of ≥4 mm were re-treated, in both control and test sides, again with the resp. treatment approach-subgingival instrumentation alone on control, and subgingival instrumentation + EPAP on test side. Clin. parameters such as probing pocket depth (PPD), bleeding on probing, and relative attachment level were recorded at baseline and 3 and 6 mo following the initial instrumentation. Subgingival plaque samples were collected at baseline, immediately post surgery, as well as at 1 wk, 1 mo, 3 mo, and 6 mo after initial instrumentation. Results : In the test group after 6 mo, a significantly larger number of initially deep pockets (PPD ≥ 5.5 mm) were reduced to shallow (PPD ≤ 3.4 mm), and a larger attachment gain was observed No statistically significant microbiol. differences could be found between test and control group. Conclusions : The results of the present study indicate that the adjunct use of subgingival airflow therapy with EPAP during initial non-surgical periodontal therapy might be beneficial in initially deep pockets (PPD ≥ 5.5 mm). In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Application In Synthesis of (2R,3S)-rel-Butane-1,2,3,4-tetraol).
(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of (2R,3S)-rel-Butane-1,2,3,4-tetraol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts