Water-Triggered Metal-Free Synthesis of Pyranopyrazoles via One-Pot Oxidation/Michael Addition/Cyclization/Dehydration Sequence. was written by Dandia, Anshu;Bansal, Sarika;Sharma, Ruchi;Parewa, Vijay. And the article was included in ChemistrySelect in 2018.HPLC of Formula: 1777-82-8 This article mentions the following:
An ”all water” strategy for the catalyst free chemo-selective synthesis of pyranopyrazoles via the reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one with benzyl alcs. was developed. Water actuated the reaction via ‘electrophile-nucleophile dual activation’ of the reactants through the concerted hydrogen bonding network and impel the reactants for C-C bond formation. Reaction proceeded by metal and catalyst free oxidation-Michael addition-cyclization-dehydration sequence. This method gave pyrano[[2, 3-c:6,5-c’]dipyrazol]-2-ones selectivity over other possible products. Furthermore, this method was also applied on the reaction of the benzyl alcs. and dimedone to give arylmethylene[bis(5,5-dimethyl-3-hydroxy-2-cyclohexene-1-ones)] in good to excellent yields. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8HPLC of Formula: 1777-82-8).
(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 1777-82-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts