Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation was written by Coe, Jotham W.;Brooks, Paige R.;Vetelino, Michael G.;Wirtz, Michael C.;Arnold, Eric P.;Huang, Jianhua;Sands, Steven B.;Davis, Thomas I.;Lebel, Lorraine A.;Fox, Carol B.;Shrikhande, Alka;Heym, James H.;Schaeffer, Eric;Rollema, Hans;Lu, Yi;Mansbach, Robert S.;Chambers, Leslie K.;Rovetti, Charles C.;Schulz, David W.;Tingley, F. David III;O’Neill, Brian T.. And the article was included in Journal of Medicinal Chemistry in 2005.Application of 230615-52-8 This article mentions the following:
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified for smoking cessation. Neuronal nicotinic acetylcholine receptors (nAChRs) mediate the dependence-producing effects of nicotine. We have pursued α4β2 nicotinic receptor partial agonists to inhibit dopaminergic activation produced by smoking while simultaneously providing relief from the craving and withdrawal syndrome that accompanies cessation attempts. Varenicline displays high α4β2 nAChR affinity and the desired in vivo dopaminergic profile. In the experiment, the researchers used many compounds, for example, 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8Application of 230615-52-8).
2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 230615-52-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts