Enantioselective Addition of Dialkylzincs to Aldehydes Catalyzed by (-)-MITH was written by Cheng, Ying-Ni;Wu, Hsyueh-Liang;Wu, Ping-Yu;Shen, Ying-Ying;Uang, Biing-Jiun. And the article was included in Chemistry – An Asian Journal in 2012.Synthetic Route of C8H9ClO This article mentions the following:
An effective catalytic system that imparts high enantioselectivity has been disclosed for the synthesis of optically active alcs., which may undergo further chem. transformations. The enantioselective alkylation of aldehydes with dialkylzincs to afford the corresponding optically active alcs. with excellent enantioselectvities has been achieved in the presence of 0.1-0.5 mol % of the camphor-derived chiral ligand (-)-2-exo-morpholinoisobornane-10-thiol (MITH) at room temperature or at 0°. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Synthetic Route of C8H9ClO).
(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C8H9ClO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts