Probing the Catalytic Promiscuity of a Regio- and Stereospecific C-Glycosyltransferase from Mangifera indica was written by Chen, Dawei;Chen, Ridao;Wang, Ruishan;Li, Jianhua;Xie, Kebo;Bian, Chuancai;Sun, Lili;Zhang, Xiaolin;Liu, Jimei;Yang, Lin;Ye, Fei;Yu, Xiaoming;Dai, Jungui. And the article was included in Angewandte Chemie, International Edition in 2015.SDS of cas: 1634-34-0 This article mentions the following:
The catalytic promiscuity of the novel benzophenone C-glycosyltransferase, MiCGT, which is involved in the biosynthesis of mangiferin from Mangifera indica, was explored. MiCGT exhibited a robust capability to regio- and stereospecific C-glycosylation of 35 structurally diverse druglike scaffolds and simple phenolics with UDP-glucose, and also formed O- and N-glycosides. Moreover, MiCGT was able to generate C-xylosides with UDP-xylose. The OGT-reversibility of MiCGT was also exploited to generate C-glucosides with simple sugar donor. Three aryl-C-glycosides exhibited potent SGLT2 inhibitory activities with IC50 values of 2.6 ×, 7.6 ×, and 7.6 × 10-7 M, resp. These findings demonstrate for the first time the significant potential of an enzymic approach to diversification through C-glycosidation of bioactive natural and unnatural products in drug discovery. In the experiment, the researchers used many compounds, for example, 2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0SDS of cas: 1634-34-0).
2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.SDS of cas: 1634-34-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts