Novel pyrazole-centered derivatives having Mono/Di chiral centered group as organocatalyst for Henry reaction was written by Cetin, Adnan;Bildirici, Ishak;Guemues, Selcuk. And the article was included in Macedonian Journal of Chemistry and Chemical Engineering in 2020.Application In Synthesis of (R)-2-Aminobutan-1-ol This article mentions the following:
The chiral substituted pyrazole compounds I, II, III and IV (R= C6H5, CH(CH3)2, C2H5) were prepared via the pyrazolo-3-chlorocarbonyl, pyrazolo-3,4-dicarboxy Me ester with pyrazole-3-isothiocyanate with different (R)-chiral amino alcs. All of the synthesized chiral compounds binding a pyrazole skeleton were investigated as organocatalysts for asym. aldol reactions between nitromethane and p-nitrobenzaldehyde in the presence of CuCl. Enantiomeric excesses and the reaction yields were found to be appropriate values. Furthermore, the best organocatalyst applied in this study was identified after careful optimization of conditions. Lastly, all of the novel compounds were subjected to computational anal. at the B3LYP/6-31++G(d,p) level of theory to obtain in-formation about their structural and electronic properties. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Application In Synthesis of (R)-2-Aminobutan-1-ol).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of (R)-2-Aminobutan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts