Novel Synthesis of Nitrogen Heterocycles Using Zirconium-Promoted Reductive Cyclization was written by Mori, Miwako;Uesaka, Noriaki;Saitoh, Fumihiko;Shibasaki, Masakatsu. And the article was included in Journal of Organic Chemistry in 1994.COA of Formula: C13H19NO This article mentions the following:
Perhydroindole derivatives were prepared from enynes using zirconium-promoted reductive cyclization. The zirconacycles derived from enynes I (R1 = benzyl, etc.; R2 = TMS, Me, etc.) were treated with iodine, isonitriles, oxygen, and carbon monoxide to give various heterocycles. The carbon-zirconium bonds of the zirconacycle could be selectively cleaved by different reagents. For example, treatment of N-(2-butynyl)-N-(2-cyclohexenyl)benzenamine I (R1 = benzyl; R2 = Me) with bis(η5-2,4-cyclopentadien-1-yl)zirconium and subsequent carbonylation gave II (18% yield). In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6COA of Formula: C13H19NO).
Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C13H19NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts