Restorative materials without Bis-GMA – myth or reality was written by Garcia, Hermano;Fernandes, Ines Caldeira;Caldeira, Jorge;Pinto, Alexandra;Carpinteiro, Ines;Azul, Ana. And the article was included in Annals of Medicine (Abingdon, United Kingdom) in 2021.Synthetic Route of C16H26O7 This article mentions the following:
IntroductionThe Bis-GMA, which is known to possess toxic properties to the human body, is part of the chem. structure of several direct dental restorative materials [1]. However, currently, there are composite resins on the market that are free of this monomer [2]. From the dental resin are released many other compounds [3]. The aim of this study was to analyze the composition of restorative materials from three different brands, and to verify whether or not Bis-GMA monomers are present in their composition Materials and methodsSamples of the Enamel plus HRi Universal Dentin (Micerium), Enamel plus HRi Bio Function (Micerium), Filtek One Bulk Fill Restorative (3 M ESPE) and Admira Fusion (VOCO) resins were prepared using three different methods: light-curing resin specimens placed for 18 min in an ethanol/water solution; light-curing resin specimens placed for 180 min in an ethanol/water solution; resin samples eluted in an acetonitrile solution without being photopolymerized These samples were analyzed using the HPLC (High Performance Liquid Chromatog.) technique.ResultsHEMA, Bis-GMA and UDMA monomers were found in the composite resin Enamel plus HRi Universal Dentin (Micerium); UDMA monomers were detected in Enamel plus HRi Bio Function (Micerium); UDMA and TEGDMA monomers were revealed in Filtek One Bulk Fill Restorative (3 M ESPE), and HEMA and UDMA peaks were obtained in Admira Fusion (VOCO). Discussion and conclusionsThe release of most of the residual monomers occurs in the first minutes after polymerization As shown in the results, the difference of the concentrations of monomers, detected by the HPLC method, between the resins eluted during 18 min and 180 min, was not significant. It was concluded that in samples of non-polymerized resins, it is possible to detect a larger number of residual monomers, and that Bis-GMA is only present in Enamel plus HRi Universal Dentin (Micerium) resin. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Synthetic Route of C16H26O7).
((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C16H26O7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts