Identification and quantification of bioactive compounds suppressing SARS-CoV-2 signals in wastewater-based epidemiology surveillance was written by Bayati, Mohamed;Hsieh, Hsin-Yeh;Hsu, Shu-Yu;Li, Chenhui;Rogers, Elizabeth;Belenchia, Anthony;Zemmer, Sally A.;Blanc, Todd;LePage, Cindy;Klutts, Jessica;Reynolds, Melissa;Semkiw, Elizabeth;Johnson, Hwei-Yiing;Foley, Trevor;Wieberg, Chris G.;Wenzel, Jeff;Lyddon, Terri;LePique, Mary;Rushford, Clayton;Salcedo, Braxton;Young, Kara;Graham, Madalyn;Suarez, Reinier;Ford, Anarose;Lei, Zhentian;Sumner, Lloyd;Mooney, Brian P.;Wei, Xing;Greenlief, C. Michael;Johnson, Marc C.;Lin, Chung-Ho. And the article was included in Water Research in 2022.Formula: C4H10O3 This article mentions the following:
Recent SARS-CoV-2 wastewater-based epidemiol. (WBE) surveillance have documented a pos. correlation between the number of COVID-19 patients in a sewershed and the level of viral genetic material in the wastewater. Efforts have been made to use the wastewater SARS-CoV-2 viral load to predict the infected population within each sewershed using a multivariable regression approach. However, reported clear and sustained variability in SARS-CoV-2 viral load among treatment facilities receiving industrial wastewater have made clin. prediction challenging. Several classes of mols. released by regional industries and manufacturing facilities, particularly the food processing industry, can significantly suppress the SARS-CoV-2 signals in wastewater by breaking down the lipid-bilayer of the membranes. Therefore, a systematic ranking process in conjugation with metabolomic anal. was developed to identify the wastewater treatment facilities exhibiting SARS-CoV-2 suppression and identify and quantify the chems. suppressing the SARS-COV-2 signals. By ranking the viral load per diagnosed case among the sewersheds, we successfully identified the wastewater treatment facilities in Missouri, USA that exhibit SARS-CoV-2 suppression (significantly lower than 5 x 1011 gene copies/reported case) and determined their suppression rates. Through both untargeted global chem. profiling and targeted anal. of wastewater samples, 40 compounds were identified as candidates of SARS-CoV-2 signal suppressors. Among these compounds, 14 had higher concentrations in wastewater treatment facilities that exhibited SARS-CoV-2 signal suppression compared to the unsuppressed control facilities. Stepwise regression analyses indicated that 4-nonylphenol, palmitelaidic acid, sodium oleate, and polyethylene glycol dioleate are pos. correlated with SARS-CoV-2 signal suppression rates. Suppression activities were further confirmed by incubation studies, and the suppression kinetics for each bioactive compound were determined According to the results of these experiments, bioactive mols. in wastewater can significantly reduce the stability of SARS-CoV-2 genetic marker signals. Based on the concentrations of these chem. suppressors, a correction factor could be developed to achieve more reliable and unbiased surveillance results for wastewater treatment facilities that receive wastewater from similar industries. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Formula: C4H10O3).
2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Formula: C4H10O3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts