Month: February 2023

Impact of glycine and erythritol/chlorhexidine air-polishing powders on human gingival fibroblasts: An in vitro study. was written by Weusmann, Jens;Deschner, James;Imber, Jean-Claude;Damanaki, Anna;Cerri, Paulo Sérgio;Leguizamón, Natalia;Beisel-Memmert, Svenja;Nogueira, Andressa Vilas Boas. And the article was included in Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft in 2022.Category: alcohols-buliding-blocks This article mentions the following:

BACKGROUND: Supra- and subgingival air-polishing has been used in periodontitis and gingivitis therapy for years. Low-abrasive types of powders have facilitated the application in subgingival areas. In this study, the cellular effects of a glycine powder and an erythritol/chlorhexidine (CHX) powder on human gingival fibroblasts (HGF) were investigated. METHODS: HGF were obtained from sound gingiva of three healthy donors. After 12 h and 24 h of incubation time, cell viability testing and, after 24 h and 48 h, a cell proliferation assay was conducted. Additionally, the individual components erythritol and CHX were investigated for cell viability. In vitro wound healing was monitored for 48 h and scanning electron microscopy (SEM) analysis was performed after 24 h. Statistical analysis was accomplished by ANOVA and post hoc Dunnett’s and Tukey’s tests (p < 0.05) were performed. RESULTS: Erythritol/CHX powder and in a lower extent, glycine powder decreased cell viability and cell proliferation. The negative effect of erythritol/CHX was mainly based on the CHX component. In vitro wound healing was negatively influenced in both types of powders compared to control. Cell size was altered in both test groups, whereas cell morphology was affected only in the erythritol/CHX group. CONCLUSIONS: The investigated powders for subgingival air-polishing can influence cell viability, morphology, and proliferation, as well as wound closure in vitro. These actions on fibroblasts are discernible, with the cytotoxic effect of erythritol/CHX powder being very clear and mainly due to the CHX component. Our results suggest that subgingivally applied powders can exert direct effects on gingival fibroblasts. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Category: alcohols-buliding-blocks).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of bioactive quinoline acting as anticancer agents and their mode of action using in silico analysis towards Aurora kinase A inhibitors was written by Narasimhamurthy, Kereyagalahally H.;Guruswamy, Dileep Kumar M.;Chandra;Kallesha, Nichhapurada;Basappa;Rangappa, Kanchugarakoppal S.. And the article was included in Chemical Data Collections in 2021.Product Details of 1777-82-8 This article mentions the following:

In the present investigation, novel quinolines have been synthesized and analyzed for their invitro cytotoxic activity against human colon cancer and lung cancer cells. Among the newly synthesized quinoline derivatives, 2-(3-chlorophenyl)-6,7-dimethoxyquinoline (Q6) showed considerable cytotoxic activity against human colon cancer (HCT116) and lung cancer (A549) cell lines with IC50 values of 25.5 ± 2.7 and 32 ± 4.7 μM resp. Since these quinolines interacted with an Aurora kinase A, we carried out the mol. docking investigation and observed that this quinoline displayed inhibitory potentials. Overall, the compound Q6 was well suited to develop a newer quinolines-based anticancer medication, especially to block cell cycle arrest through Aurora kinase A inhibitors in human cancer. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Product Details of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Induction of a Preferred Sense of Twist in Flexible Diphenyls by Carbohydrate Scaffolds. Synthesis of Two “Naked” Ellagitannin Analogous was written by Capozzi, Giuseppe;Ciampi, Cinzia;Delogu, Giovanna;Menichetti, Stefano;Nativi, Cristina. And the article was included in Journal of Organic Chemistry in 2001.Synthetic Route of C6H14O6 This article mentions the following:

The synthesis of “naked ” ellagitannin analogs, having a preferred sense of twist of the di-Ph moiety, with a rhamnose and a glucose template, is reported. A clear induction in the chirality of the di-Ph moiety, mediated through a 10-membered ring via ester linkages, was observed The chiral scaffold of glucose (diequatorial 2,3-hydroxyl groups) exerts a remarkable stronger atropdiastereoselective effect onto the diphenoyl group than the rhamnose ring (axial-equatorial 2,3-hydroxyl groups), according to the Schmidt-Haslam hypothesis. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Synthetic Route of C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stimulation of Secondary Metabolites and γ-Terpinene Synthase by Silver Nanoparticles in Callus Cultures of Carum carvi was written by Dehghani-Aghchekohal, Zahra;Omidi, Mansoor;Azizinezhad, Reza;Etminan, Alireza. And the article was included in Applied Biochemistry and Biotechnology in 2022.Application In Synthesis of 5-Isopropyl-2-methylphenol This article mentions the following:

Biotechnol. and nanotechnol. are important tools for understanding biochem. pathways. They can be used efficiently for stimulating and increasing the production of secondary metabolites in medicinal plants. The present study aimed to identify the γ-terpinene synthase gene (CcTPS2) as an effective contributor to the biosynthetic pathway of monoterpenes. The effects of silver nanoparticles (AgNPs; 50 and 100 mg l- 1) and time (24 and 48 h) were examined on secondary metabolites in cell suspension cultures of Carum carvi. This involved the identification, isolation, and sequencing of a partial sequence in the CcTPS2 gene of C. carvi. The genomic sequence of CcTPS2 comprised 292 bp which were organized into two exons (110 and 82 bp) and one intron (100 bp), while the cDNA was 192 bp. In the scale of nucleotides, the CcTPS2 gene showed 96% similarity with the TPS2 gene of Oliveria decumbens. We generated sequence data of the CcTPS2 gene for the first time in this species, thereby enabling further developments in understanding the mol. mechanisms responsible for terpene biosynthesis and other chem. derivatives in C. carvi. The results of GC/MS and GC/FID showed that AgNPs strongly affected the secondary metabolites in cell suspension cultures of C. carvi. According to the results, the AgNPs (50 mg l- 1) increased p-cymene and carvone contents in comparison with the control. The exposure of plants to 100 mg l- 1 AgNPs induced the production of thymol and carvacrol. The results of real-time PCR revealed that the exposure of plants to 100 mg l- 1 AgNPs caused a significant upregulation of CcTPS2 expression for 24 h. These cell suspension cultures were elicited by AgNPs, the application of which proved as an effective method to improve the production of secondary metabolites in vitro. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Application In Synthesis of 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application In Synthesis of 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effect of antioxidant supplementation on skeletal muscle and metabolic profile in aging mice was written by Tsukamoto-Sen, Sakuka;Kawakami, Shinpei;Maruki-Uchida, Hiroko;Ito, Ryouichi;Matsui, Naoko;Komiya, Yuki;Mita, Yoshitaka;Morisasa, Mizuki;Goto-Inoue, Naoko;Furuichi, Yasuro;Manabe, Yasuko;Morita, Minoru;Fujii, Nobuharu L.. And the article was included in Food & Function in 2021.Formula: C14H12O4 This article mentions the following:

Aging induces drastic changes in muscle mass and function (sarcopenia); however, the detailed mechanisms underlying sarcopenia remain poorly understood. Recent studies suggested that age-related increases in oxidative stress induce muscle atrophy. In this study, we investigated the effect of 6-mo supplementation of antioxidants, specifically piceatannol (PIC) and enzymically modified isoquercitrin (EMIQ), on age-related physiol. changes, including skeletal muscle weight and quality, in 25-mo-old (OLD) mice, compared to in 4-mo-old (young, YNG) C57BL/6J mice. Muscle weight corrected by body weight significantly declined in OLD mice, compared to in YNG mice. The control OLD mice also showed changes in the expression of genes related to muscle fiber type, reduced locomotor activity, and increased oxidative stress markers in blood. Consistent with the muscle weight and quality changes, whole-body fat oxidation during sedentary conditions and exercise periods in control OLD mice was significantly lower than that in YNG mice. Interestingly, compared to the control OLD mice, the PIC- or EMIQ-fed OLD mice showed higher fat oxidation Furthermore, EMIQ, but not PIC, increased locomotor activity, the expression of genes encoding antioxidant enzymes, and suppressed the carbonylated protein in the skeletal muscle of OLD mice. These results suggested that chronic antioxidant intake could alleviate aging-related muscle function changes. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Formula: C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C14H12O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cytostatic activity of some novel amidocarbamate derivatives of ketoprofen was written by Sahoo, Prasanta Kumar;Behera, Pritishova. And the article was included in Journal of Cancer Therapy in 2010.HPLC of Formula: 59960-32-6 This article mentions the following:

A series of novel ketoprofen derivatives bearing both amide and carbamate functionalities were prepared using benzotriazole. Selective reduction of ketoprofen produced 3-(HOCHPh)C₆H₄CHMeCO₂H, which reacts with one or two moles of 1-benzotriazolecarboxylic acid chloride to give the mono- and bis(benzotriazole) derivatives, the latter being aminated to give the title products. Antioxidative screenings revealed that the prepared compounds possess excellent lipid peroxidation inhibition at 0.1 mM concentration 3-(RCO₂CHPh)C₆H₄CHMeCOR [R = 1-benzotriazolyl, NHCH₂Ph] also showed high soybean lipoxygenase inhibition activity, whereas the amidocarbamate derivatives of ketoprofen showed only weak reducing activity against 1,1-diphenyl-2-picrylhydrazyl radicals. No selective effects were noted for the tested compounds against a broad variety of DNA and RNA viruses. The majority of the compounds show IC₅₀ values around 10-25 μM, pointing to a relatively minor role of the R substituents on the core structure for cytostatic activity, as long as a bulky lipophilic (cyclic) entity is present. Also, the presence of the amide groups might play an important role to eventually exert cytostatic potential. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6HPLC of Formula: 59960-32-6).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 59960-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stable Dye-Sensitized Solar Cells Based on Copper(II/I) Redox Mediators Bearing a Pentadentate Ligand was written by Rui, Hailong;Shen, Junyu;Yu, Ze;Li, Lihua;Han, Hongxian;Sun, Licheng. And the article was included in Angewandte Chemie, International Edition in 2021.HPLC of Formula: 1122-71-0 This article mentions the following:

In recent years, copper redox mediators have attracted growing interest in dye-sensitized solar cells (DSCs). However, experiments revealed that ubiquitously used Lewis-base additives in the electrolytes coordinate to the CuII species, which restricts further enhancement of device performance and stability. We report the application of copper complexes endowed with diamine-tripyridine pentadentate ligands, [Cu(tpe)]^2+/+ (tpe=N-benzyl-N,N,N-tris(pyridin-2-ylmethyl)ethylenediamine) and [Cu(tme)]^2+/+ (tme=N-benzyl-N,N,N-tris(6-methylpyridin-2-ylmethyl)ethylenediamine), as redox mediators in DSCs. Exptl. measurements demonstrate that the coordination environment of Cu(II) complexes with pentadentate ligands remains unchanged in the presence of TBP, which is in stark contrast to the state-of-the-art bipyridyl counterpart. DSCs based on [Cu(tme)]^2+/+ complexes exhibit an excellent long-term stability and maintain more than 90 % of the initial efficiency after 400 h under continuous illumination, which outperform the reference devices incorporating the bipyridyl counterpart (less than 80 %) under identical conditions. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0HPLC of Formula: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Evaluation of aroma characteristics in grass carp mince as affected by different washing processes using an E-nose, HS-SPME-GC-MS, HS-GC-IMS, and sensory analysis was written by Xiao, Naiyong;Xu, Huiya;Jiang, Xin;Sun, Tongtong;Luo, Yixuan;Shi, Wenzheng. And the article was included in Food Research International in 2022.Recommanded Product: Oct-1-en-3-ol This article mentions the following:

The aroma characteristics of grass carp mince washed in four processes were analyzed via electronic nose (E-nose), headspace solid-phase microextraction-gas chromatog.-mass spectrometry (HS-SPME-GC-MS), headspace gas chromatog.-ion mobility spectrometry (HS-GC-IMS), and sensory anal. techniques. Significant differences were revealed in the E-nose and sensory anal. results of the aroma characteristics of grass carp mince samples washed via different washing processes, while fifty-seven volatile compounds (thirteen aldehydes, eighteen alcs., two ketones, eighteen hydrocarbons, two aromatic compounds, one furan, and two other compounds) and twenty volatile compounds (five aldehydes, four ketones, six alcs., four esters, and one acid) were identified via HS-SPME-GC-MS and HS-GC-IMS of the Raw and washed grass carp mince samples, resp. All these techniques revealed that the types and relative contents of volatile compounds in the grass carp mince decreased significantly and differently after each of the four washing processes. Moreover, compared with the water and saline solution washing processes, washing with weak alk. solution processes exhibited the most significant removal effect on the volatile compounds of grass carp mince. Besides, the sensory anal. results also showed that weak alk. solution washing processes (washing twice with pure water and once with 0.3% sodium bicarbonate solution) may be most effective in removing fishy off-odor compounds and contributing to a better overall aroma profile in grass carp mince. The findings of this study may provide some basic knowledge for the rational screening of washing methods in the production of high-quality grass carp surimi. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Recommanded Product: Oct-1-en-3-ol).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: Oct-1-en-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Catalytic hydrosilylation of carbonyl compounds by hydrido thiophenolato iron(II) complexes was written by Xue, Benjing;Sun, Hongjian;Niu, Qingfen;Li, Xiaoyan;Fuhr, Olaf;Fenske, Dieter. And the article was included in Catalysis Communications in 2017.Computed Properties of C7H6Cl2O This article mentions the following:

The hydrosilylation of aldehydes RCHO (R = C₆H₅, 4-ClC₆H₅, furan-2-yl, etc.) and ketones R¹C(O)R² (R¹ = C₆H₅, R² = CH₃; R¹ = naphthalen-2-yl, R² = CH₃; R¹R² = -(CH₂)₅-) under mild conditions with hydrido thiophenolato iron(II) complexes I (R³ = H, 2-Si(CH₃)₃, 3-OCH₃, 4-CH₃) as catalysts and (EtO)₃SiH as an efficient reducing agent in the yields up to 95% has been reported. Among them complex I (R³ = H) is the best catalyst. Complex I (R³ = H) could also be used as catalyst to reduce the α,β-unsaturated carbonyl compounds, e.g., 3-phenylprop-2-ynal selectively to the α,β-unsaturated alcs., e.g., 3-phenylprop-2-yn-1-ol in high yields. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Computed Properties of C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iron(III) trifluoroacetate [Fe(O₂CCF₃)₃] catalyzed epoxide opening with amines was written by Erturk, Erkan;Demir, Ayhan S.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2008.Recommanded Product: Trans-2-(benzylamino)cyclohexanol This article mentions the following:

Non-hygroscopic, non-toxic, and readily available iron(III) trifluoroacetate [Fe(O₂CCF₃)₃] was found to be a highly regioselective catalyst for the ring opening of a wide variety of epoxides with diverse amines under solvent-free conditions. The stereospecific ring opening of (R)-styrene oxide with p-anisidine in the presence of 1 mol% of Fe(O₂CCF₃)₃ gave 2-(p-methoxyphenylamino)-2-phenylethanol (5b) in enantiopure form (>99% ee) within 60 min. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Recommanded Product: Trans-2-(benzylamino)cyclohexanol).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: Trans-2-(benzylamino)cyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts