Month: January 2023

A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates was written by Zhang, Penghui;Gao, Di;An, Keli;Shen, Qi;Wang, Chen;Zhang, Yuchao;Pan, Xiaoshu;Chen, Xigao;Lyv, Yifan;Cui, Cheng;Liang, Tingxizi;Duan, Xiaoman;Liu, Jie;Yang, Tielin;Hu, Xiaoxiao;Zhu, Jun-Jie;Xu, Feng;Tan, Weihong. And the article was included in Nature Chemistry in 2020.Recommanded Product: (3-Methyl-2-nitrophenyl)methanol This article mentions the following:

Abstract: Stimuli-responsive biomaterials that contain logic gates hold great potential for detecting and responding to pathol. markers as part of clin. therapies. However, a major barrier is the lack of a generalized system that can be used to easily assemble different ligand-responsive units to form programmable nanodevices for advanced biocomputation. Here we develop a programmable polymer library by including responsive units in building blocks with similar structure and reactivity. Using these polymers, we have developed a series of smart nanocarriers with hierarchical structures containing logic gates linked to self-immolative motifs. Designed with disease biomarkers as inputs, our logic devices showed site-specific release of multiple therapeutics (including kinase inhibitors, drugs and short interfering RNA) in vitro and in vivo. We expect that this ‘plug and play’ platform will be expanded towards smart biomaterial engineering for therapeutic delivery, precision medicine, tissue engineering and stem cell therapy. In the experiment, the researchers used many compounds, for example, (3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8Recommanded Product: (3-Methyl-2-nitrophenyl)methanol).

(3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: (3-Methyl-2-nitrophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rapid Glycolysis of Waste Polyethylene Terephthalate Fibers via a Stepwise Feeding Process was written by Lei, Dandan;Sun, Xiao-Li;Hu, Shasha;Cheng, Huibin;Chen, Qinghua;Qian, Qingrong;Xiao, Qiao;Cao, Changlin;Xiao, Lireng;Huang, Baoquan. And the article was included in Industrial & Engineering Chemistry Research in 2022.Category: alcohols-buliding-blocks This article mentions the following:

Recycling waste polyethylene terephthalate (PET) fibers is critical for both environmental and resource protection. However, the PET fiber possesses good chem. stability and high crystallinity, resulting in the conversion of PET. Herein, we developed a strategy of stepwise feeding process to recycle PET fibers and recover the potential monomer by adding it to the glycolysis agent diethylene glycol after it had been warmed up to reaction temperature The results show a significant increase in the PET fiber conversion (92.5%) and yield of water-soluble products (70.4%) in 90 min as compared to a one-step feeding process of 28 and 14.4%, resp. These water-soluble products are monomers and dimers which are confirmed by Fourier transform IR spectroscopy, NMR spectroscopy, mass spectroscopy, and high-performance liquid chromatog. It is also obviously found that the conversion of PET and yields of fibers are lower than those of bottle flakes and particles. In addition, a ‘column shrinkage model’ is proposed to describe the glycolysis process of the fibers. The apparent reaction activation energy of fibers was derived as 27.19 kJ/mol, which is somewhat higher than those of PET bottle flakes and particles. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Category: alcohols-buliding-blocks).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Environmentally relevant exposure to TBBPA and its analogues may not drastically affect human early cardiac development was written by Zhao, Miaomiao;Yin, Nuoya;Yang, Renjun;Li, Shichang;Zhang, Shuxian;Faiola, Francesco. And the article was included in Environmental Pollution (Oxford, United Kingdom) in 2022.Electric Literature of C4H10O3 This article mentions the following:

Tetrabromobisphenol A (TBBPA) and its substitutes and derivatives have been widely used as halogenated flame retardants (HFRs), in the past few decades. As a consequence, these compounds are frequently detected in the environment, as well as human bodily fluids, especially umbilical cord blood and breast milk. This has raised awareness of their potential risks to fetuses and infants. In this study, we employed human embryonic stem cell differentiation models to assess the potential developmental toxicity of six TBBPA-like compounds, at human relevant nanomolar concentrations To mimic early embryonic development, we utilized embryoid body-based 3D differentiation in presence of the six HFRs. Transcriptomics data showed that HFR exposure over 16 days of differentiation only interfered with the expression of a few genes, indicating those six HFRs may not have specific tissue/organ targets during embryonic development. Nevertheless, further analyses revealed that some cardiac-related genes were dysregulated. Since the heart is also the first organ to develop, we employed a cardiac differentiation model to analyze the six HFRs’ potential developmental toxicity in more depth. Overall, HFRs of interest did not significantly disturb the canonical WNT pathway, which is an essential signal transduction pathway for cardiac development. In addition, the six HFRs showed only mild changes in gene expression levels for cardiomyocyte markers, such as NKX2.5, MYH7, and MYL4, as well as a significant down-regulation of some but not all the epicardial and smooth muscle cell markers selected. Taken together, our results show that the six studied HFRs, at human relevant concentrations, may impose negligible effects on embryogenesis and heart development. Nevertheless, higher exposure doses might affect the early stages of heart development. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Electric Literature of C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C4H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Heterogeneous asymmetric transfer hydrogenation with mesoporous silica SBA-15-supported Ru-TsCHDA catalyst was written by Jung, Ji-Young;Sarkar, M. S.;Jin, Myung-Jong. And the article was included in Studies in Surface Science and Catalysis in 2007.Computed Properties of C8H9ClO This article mentions the following:

Chiral TsCHDA was successfully anchored on SBA-15 silica material. The mesoporous system was used as an efficient heterogeneous chiral ligand in the asym. transfer hydrogenation of ketones. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Computed Properties of C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Computed Properties of C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fe₃O₄@CS-Ni: An efficient and recyclable magnetic nanocatalyst for α-alkylation of ketones with benzyl alcohols by borrowing hydrogen methodology was written by Taheri-Torbati, Mina;Eshghi, Hossein. And the article was included in Applied Organometallic Chemistry in 2022.Application In Synthesis of (4-Chlorophenyl)methanol This article mentions the following:

This paper reports a heterogeneous magnetic impressive nickel catalyst in which Fe₃O₄ nanoparticles have been coated with chitosan and decorated with nickel nanoparticles (Fe₃O₄@CS-Ni). This catalyst has been used for direct α-alkylation of aryl ketones with substituted benzyl alcs. through borrowing hydrogen and dehydrogenation mechanism that affords the corresponding α-benzyl ketones, with good to excellent yield. The core-shell morphol. has been confirmed with different anal. techniques such as Fourier-transform IR (FT-IR), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), SEM (SEM), transmission electron microscopy (TEM), SEM mapping, energy-dispersive X-ray (EDX), inductively coupled plasma (ICP), and thermogravimetric anal. (TGA). Moreover, the catalyst could be recovered from the reaction mixture by using an external magnetic field and reused for six successive cycles without a considerable decrease in catalytic activity. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Application In Synthesis of (4-Chlorophenyl)methanol).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of (4-Chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and structures of gallium alkoxides was written by Basharat, Siama;Knapp, Caroline E.;Carmalt, Claire J.;Barnett, Sarah A.;Tocher, Derek A.. And the article was included in New Journal of Chemistry in 2008.Electric Literature of C6H15NO This article mentions the following:

Homoleptic gallium tris(alkoxides), [Ga(OR)₃]₂ (R = CH₂CH₂NMe₂ (2), CHMeCH₂NMe₂ (3), CMe₂CH₂OMe (4), CH₂CH₂OMe (5)), were prepared by the reaction of [Ga(NMe₂)₃]₂ (1) and excess ROH in toluene at room temperature Compounds 2–5 were isolated as colorless oils. The side-products, [Ga(OCH₂CH₂NMe₂)₂Cl] (6), [Ga(OCHMeCH₂NMe₂)₂Cl] (7) and [Ga(OCMe₂CH₂OMe)Cl₂]₂ (8) were also isolated in low yield during the synthesis of 2, 3 and 4, resp. However, compounds 6 and 7 were also prepared directly from the reaction of [Ga(NMe₂)₂Cl] and 2 equiv of ROH. Similarly, compound 8 was isolated from the reaction of [Ga(NMe₂)Cl₂] and 1 equiv of HOCMe₂CH₂OMe. Single crystal x-ray crystallog. showed that the gallium bis(alkoxides) (6 and 7) are monomeric in the solid state with the Ga center adopting a distorted trigonal bipyramidal geometry. In contrast, the gallium mono(alkoxide) 8 is dimeric. In the experiment, the researchers used many compounds, for example, 1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9Electric Literature of C6H15NO).

1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Antibacterial and antibiofilm activities and synergism with florfenicol from the essential oils of Lippia sidoides and Cymbopogon citratus against Aeromonas hydrophila was written by Felix e Silva, Altiery;Pires, Isabelle C.;da Costa, Mateus M.;Melo, Jose F. B.;Lorenzo, Vitor P.;de Melo, Fulvio V. S. T.;Copatti, Carlos E.. And the article was included in Journal of Applied Microbiology in 2022.Formula: C10H22O3 This article mentions the following:

Aeromonas hydrophila is an opportunistic bacterium, with a high capacity for biofilm production, which can cause severe damage in aquaculture. The objective of this study was to identify the chem. compounds of the essential oils of Lippia sidoides (EOLS) and Cymbopogon citratus (EOCC), and to evaluate the biocidal, antibiofilm and synergistic action with the antimicrobial florfenicol of these essential oils (EOs) against A. hydrophila. The antibacterial activity of EOLS and EOCC was verified by the min. bactericidal concentration and by the action of these EOs against both forming and consolidated biofilms. The synergistic activity of EOs with florfenicol was performed using the checkerboard technique. The main component of EOLS and EOCC was carvacrol (44.50%) and α-citral (73.56%), resp. Both EOs showed weak inhibitory activity (≥3125.00 μg ml-1). Two bacterial isolates were able to produce biofilm, and EOLS and EOCC acted upon the bacterial isolates to prevent biofilm formation. A bactericidal effect was verified for EOLS in the previously consolidated biofilm for both isolates and for EOCC in only one of the isolates. In general, EOLS had a synergistic effect with florfenicol, while EOCF had an additive effect. Both EOs were able to interfere with biofilm formation and did not have an antagonistic effect in combination with florfenicol. The best results were found for EOLS, which showed a synergistic effect with florfenicol and the ability to interfere in the formation of consolidated biofilm. This study highlights the potential of EOLS and EOCC to interfere in biofilm and act in synergy with florfenicol to reduce the occurrence of A. hydrophila. Development of these compounds may contribute to the development of herbal medicines in aquaculture. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Formula: C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The Friedel-Crafts reaction. VI. Further evidence for γ-substitution in resorcinol and orcinol derivatives was written by Desal, R. D.;Vakil, V. M.. And the article was included in Proceedings – Indian Academy of Sciences, Section A in 1940.Formula: C9H10O3 This article mentions the following:

AcCl (20 cc.) was added gradually to a solution of 12 g. anhydrous orcinol and 26 g. anhydrous AlCl₃ in 150 cc. PhNO₂ and the mixture allowed to stand for 24 h., then heated on the water bath for 2 h., yielding 8 g. γ-orcacetophenone (I), needles, m. 142-4°; oxime, needles, m. 211-12°; p-nitrophenylhydrazone, red microcrystalline plates, m. 245° (in 3 out of 7 experiments a mixture of β-and γ-orcacetophenones was formed instead of only the γ-variety; these were separated by crystallization from C₆H₆). Clemmensen reduction of I yielded 2-ethyl-5-methylresorcinol, needles, m. 135°. A mixture of 14 g. anhydrous AlCl₃, 12 g. orcinol and 17 g. BzCl in 75 cc. PhNO₂, after standing overnight, was heated on the water bath for 1 h., yielding after trituration with NaHCO₃ solution and crystallization of the residue from C₆H₆, pale yellow needles of 2,4-dihydroxy-5-methylbenzophenone, m. 138°. Treatment of either β- or γ-orcacetophenone in PhNO₂ solution with Ac₂O in the presence of anhydrous AlCl₃ gave lustrous needles of 2,4-diacetyl-5-methylresorcinol, m. 95°, giving a purple-red color with FeCl₃; p-nitrophenylhydrazone, red microcrystalline needles, m. 242°. A mixture of 20 g. resacetophenone, 24 g. BzCl and 18 g. of AlCl₃ in 200 cc. PhNO₂ was heated on the water bath for 2 h.; after treatment of the product with NaHCO₃, solution in 5% NaOH, acidification of the solution and exhaustive extraction of the dry solid with petr. ether, the residue was crystallized from C₆H₆ and from alc., yielding 0.8 g. of pale yellow lustrous needles of 2-benzoyl-4-acetylresorcinol (II), m. 165°, gives a red color with FeCl₃ solution; p-nitrophenylhydrazone, red microcrystalline powder, m. above 300°; the petr. ether solution yielded lustrous plates (from alc.) of 4-O-benzoyl-resacetophenone (III), m. 110° mono-Br derivative, lustrous needles from alc., m. 176°. II could not be brominated at room temperature either in CHCl₃ or glacial AcOH; it could not be condensed with Ac₂O in presence of anhydrous AlCl₃. III (2 g.) heated with 4 g. anhydrous AlCl₃ at 140° for 1.5 h. underwent the Fries transformation to give II. BzCl (1.7 g.) was gradually added to 2 g. Me 2,4-dihydroxy-5-acetylbenzoate and 1.6 g. anhydrous AlCl₃ in 50 cc. PhNO₂ and the mixture heated for 6 h. at 130-40° and allowed to stand overnight, yielding 42% of Me 2,4-dihydroxy-3-benzoyl-5-acetylbenzoate (IV), needles, m. 204°; its alc. solution gives a red color with FeCl₃. Saponification of IV with KOH gave the acid (V), needles, m. 217°, whose alc. solution gave a red color with FeCl₃. V heated at 220-25° for 1 h. gave pale yellow needles (from alc.) of 2-benzoyl-4-acetylresorcinol, m. 165°. A mixture of 10 g. anhydrous AlCl₃, 7 g. 4-benzoylresorcinol, 4 g. Ac₂O and 75 cc. PhNO₂ was heated 6 h. on the water bath; the product after solution in 5% NaOH solution and precipitation with acid was exhaustively extracted with petr. ether, yielding, (1) upon concentration of the petr. ether solution, 30% of 2-acetyl-4-benzoyl-resorcinol, needles, m. 107-8°, whose alc. solution gave a wine-red color with FeCl₃ (p-nitrophenylhydrazone, red microcrystalline powder, m. 227-9°), and (2) after crystallization of the residue from dilute alc., 5% of 2,6-diacetyl-4-benzoyl-resorcinol, m. 151°, whose alc. solution gave a cherry-red color with FeCl₃ (p-nitrophenylhydrazone, reddish microcrystalline powder, m. 288-90° (decomposition)). 2-Acetylresorcinol (1 g.), 1 g. AlCl₃ and 1.2 g. BzCl in 30 cc. PhNO₂ after standing at ordinary temperature was heated 1 h. on the water bath. After treatment with NaHCO₃ solution, the residue was extracted with petr. ether; the petr. ether solution upon concentration gave 2-acetyl-4-benzoylresorcinol (VI), needles, m. 108°. Friedel-Crafts condensation of VI with Ac₂O yielded 2,6-diacetyl-4-benzoylresorcinol, m. 151°. In the experiment, the researchers used many compounds, for example, 2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0Formula: C9H10O3).

2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Formula: C9H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vaginal estrogen and mammogram results: case series and review of literature on treatment of genitourinary syndrome of menopause (GSM) in breast cancer survivors. was written by Zuo, Stephanie Wang;Wu, Harold;Shen, Wen. And the article was included in Menopause (New York, N.Y.) in 2018.Formula: C24H23ClO2 This article mentions the following:

OBJECTIVE: To examine mammographic density before and after at least 1 year of vaginal estrogen use in a small cohort of healthy postmenopausal women and women with a personal history of breast cancer. METHODS: We extracted data via chart review of patients from a single practitioner’s menopause specialty clinic in Baltimore, MD. Mammographic change was primarily determined via the Bi-RADS scoring system, including the Bi-RADS density score. In addition, we conduct a narrative review of the current literature on the usage of local estrogen therapy, and systemic and local alternatives in the treatment of genitourinary syndrome of menopause (GSM) in breast cancer survivors. RESULTS: Twenty healthy postmenopausal women and three breast cancer survivors fit our inclusion criteria. Amongst these two groups, we did not find an increase in mammographic density after at least 1 year and up to 18 years of local vaginal estrogen. Ospemifene use in one patient did not appear to be associated with any change in Bi-RADS score. Our narrative review found little data on the effects of vaginal estrogen therapy or newer alternative systemic therapies such as ospemifene on mammographic density. CONCLUSIONS: Low-dose vaginal estrogen use for 1 or more years in a small cohort of women with GSM did not appear to be associated with any changes in breast density or Bi-RADS breast cancer risk scores in the majority of study participants, including three breast cancer survivors. Larger long-term controlled clinical trials should be conducted to examine the effects of low-dose vaginal estrogen on mammographic density in women with and without a personal history of breast cancer. Furthermore, relative efficacy and risk of vaginal estrogen compared with other forms of treatment for GSM should also be studied in long-term trials. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Formula: C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Identification and functional characterization of a γ-terpinene synthase in Nigella sativa L (black cumin) was written by Elyasi, Rizan;Majdi, Mohammad;Krause, Sandra T.;Kucukay, Nagihan;Azizi, Abdolbaset;Degenhardt, Jorg. And the article was included in Phytochemistry (Elsevier) in 2022.Electric Literature of C10H14O This article mentions the following:

Nigella sativa (Black cumin) has many applications in food and pharmaceutical industries. Thymoquinone has been considered as a main effective compound in N. sativa seeds and attracted researchers’ attention mainly due to its medicinal potential. In this study, the essential oil components of leaves, flowers and seed developmental stages including half black seeds, soft black seeds and hard black seeds were analyzed in N. sativa. Whereas no terpenes were detected in flowers and leaves, seeds showed an essential oil composition that increased in its thymoquinone content during seed maturation. To study the proposed first step of thymoquinone biosynthesis, the formation of γ-terpinene from geranyl diphosphate (GDP), we identified and functionally characterized a γ-terpinene synthase (NsTPS1) in N. sativa. This monoterpene synthase was identified in RNA sequence data derived from seeds. After heterologous expression in Escherichia coli, partially purified NsTPS1 converted GDP to γ-terpinene. NsTPS1 is the first functionally characterized terpene synthase from N. sativa and displays a higher similarity to other terpene synthases from Ranunculaceae than known γ-terpinene synthases from more distant plant species. Characterization of NsTPS1 elucidates the first dedicated step in the biosynthesis of thymoquinone in N. sativa and paves the way towards metabolic engineering for high-level thymoquinone production A full-length N. sativa monoterpene synthase (NsTPS1) was identified and deposited in Genbank with the accession number OM856342. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Electric Literature of C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Electric Literature of C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts