Month: January 2023

Nickel-Catalyzed Decarboxylative Cross-Coupling of Bicyclo[1.1.1]pentyl Radicals Enabled by Electron Donor-Acceptor Complex Photoactivation was written by Polites, Viktor C.;Badir, Shorouk O.;Keess, Sebastian;Jolit, Anais;Molander, Gary A.. And the article was included in Organic Letters in 2021.Product Details of 68716-49-4 This article mentions the following:

The synthesis and Ni-catalyzed functionalization of BCP redox-active esters with (hetero)aryl bromides via the action of a photoactive electron donor-acceptor complex were reported. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Product Details of 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Product Details of 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design, synthesis, anti-proliferative evaluation and docking studies of 1H-1,2,3-triazole tethered ospemifene-isatin conjugates as selective estrogen receptor modulators was written by Kumar, Sumit;Gu, Liang;Palma, Gabriella;Kaur, Mandeep;Singh-Pillay, Ashona;Singh, Parvesh;Kumar, Vipan. And the article was included in New Journal of Chemistry in 2018.Related Products of 128607-22-7 This article mentions the following:

A library of 1H-1,2,3-triazole-tethered ospemifene-isatin and ospemifene-spiroisatin conjugates have been synthesized and evaluated for their anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines. The evaluation studies revealed that compound 11j was the most potent with an IC₅₀ value of 1.56 μM against the MCF-7 cell line. Compounds 11k and 11l also displayed a similar trend, with several-fold lower effective concentrations in ER+ cells than in ER- cells. SAR studies revealed that conjugates having a bromo-substituent at the C-5 and C-7 positions of the isatin ring with ethyl/propyl as the spacer were observed to be active with the most potent compound being ∼30 times more potent than Tamoxifen against the MCF-7 cell line. The evaluation results were further supported by docking studies and the stronger binding affinity of the synthesized conjugates was attributed to their greater structural bulk and greater occupation of the ERα active site. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Related Products of 128607-22-7).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Related Products of 128607-22-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Activation of Remote meta-C-H Bonds in Arenes with Tethered Alcohols: A Salicylonitrile Template was written by Zhang, Lanlan;Zhao, Chaoyue;Liu, Yang;Xu, Jiancong;Xu, Xiufang;Jin, Zhong. And the article was included in Angewandte Chemie, International Edition in 2017.Application of 94022-96-5 This article mentions the following:

Palladium-catalyzed activation of remote meta-C-H bonds in arenes containing tethered alcs. was achieved with high regioselectivity by using a nitrile template. Computational studies on the macrocyclic transition state of the regioselectivity-determining C-H activation steps revealed that both the C-N-Ag angles and gauche conformations of Ph ether play an extremely important role in the meta selectivity. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Application of 94022-96-5).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 94022-96-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and Catalytic Activity of Iron Hydride Ligated with Bidentate N-Heterocyclic Silylenes for Hydroboration of Carbonyl Compounds was written by Qi, Xinghao;Zheng, Tingting;Zhou, Junhao;Dong, Yanhong;Zuo, Xia;Li, Xiaoyan;Sun, Hongjian;Fuhr, Olaf;Fenske, Dieter. And the article was included in Organometallics in 2019.Product Details of 1777-82-8 This article mentions the following:

We report the synthesis of a novel bidentate N-heterocyclic silylene (NHSi) ligand, N-(LSi:)-N-methyl-2-pyridinamine (1) (L = PhC(N^tBu)₂), and the first bischelate disilylene iron hydride I, [(Si,N)(Si,C)Fe(H)(PMe₃)] (2, R = ^tBu), and monosilylene iron hydride, [(Si,C)Fe(H)(PMe₃)₃] (2‘), through C_sp²-H activation of the NHSi ligand. Compounds 1 and 2 were fully characterized by spectroscopic methods and single-crystal X-ray diffraction anal. D. functional theory calculations indicated the multiple-bond character of the Fe-Si bonds and the π back-donation from Fe(II) to the Si(II) center. Moreover, the strong donor character of ligand 1 enables 2 to act as an efficient catalyst for the hydroboration reaction of carbonyl compounds at room temperature Chemoselective hydroboration is attained under these conditions. This might be the first example of hydroboration of ketones and aldehydes catalyzed by a silylene hydrido iron complex. A catalytic mechanism was suggested and partially exptl. verified. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Product Details of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Integrative analysis of metabolomics and proteomics reveals amino acid metabolism disorder in sepsis was written by Chen, Qi;Liang, Xi;Wu, Tianzhou;Jiang, Jing;Jiang, Yongpo;Zhang, Sheng;Ruan, Yanyun;Zhang, Huaping;Zhang, Chao;Chen, Peng;Lv, Yuhang;Xin, Jiaojiao;Shi, Dongyan;Chen, Xin;Li, Jun;Xu, Yinghe. And the article was included in Journal of Translational Medicine in 2022.Formula: C16H16O3 This article mentions the following:

Sepsis is defined as a systemic inflammatory response to microbial infections with multiple organ dysfunction. This study analyzed untargeted metabolomics combined with proteomics of serum from patients with sepsis to reveal the underlying pathol. mechanisms involved in sepsis. A total of 63 patients with sepsis and 43 normal controls were enrolled from a prospective multicentre cohort. The biol. functions of the metabolome were assessed by coexpression network anal. A mol. network based on metabolomics and proteomics data was constructed to investigate the key mols. Untargeted metabolomics anal. revealed widespread dysregulation of amino acid metabolism, which regulates inflammation and immunity, in patients with sepsis. Seventy-three differentially expressed metabolites (|log₂ fold change| > 1.5, adjusted P value < 0.05 and variable importance in the projection (VIP) > 1.5) that could predict sepsis were identified. External validation of the hub metabolites was consistent with the derivation results (area under the receiver operating characteristic curve (AUROC): 0.81-0.96/0.62-1.00). The pentose phosphate pathway was found to be related to sepsis-associated encephalopathy. Phenylalanine metabolism was associated with sepsis-associated acute kidney injury. The key mol. alterations of the multiomics network in sepsis compared to normal controls implicate acute inflammatory response, platelet degranulation, myeloid cell activation involved in immune response and phenylalanine, tyrosine and tryptophan biosynthesis, and arginine biosynthesis. Integrated anal. of untargeted metabolomics and proteomics revealed characteristic metabolite and protein alterations in sepsis, which were mainly involved in inflammation-related pathways and amino acid metabolism This study depicted the pathol. characteristics and pathways involved in sepsis and potential therapeutic targets. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Formula: C16H16O3).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C16H16O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analysis of sugar components related to heartwood formation in young Swietenia mahagoni (L.) Jacq trees was written by Arisandi, Rizki;Marsoem, Sri Nugroho;Lukmandaru, Ganis;Sutapa, Johanes Pramana Gentur. And the article was included in Journal of Wood Chemistry and Technology in 2022.HPLC of Formula: 149-32-6 This article mentions the following:

This study aims to investigate the sugar components which play an important role in the process of heartwood formation in young Swietania mahagoni. The methanol-water (70/30, volume/volume) extract was analyzed by GC-MS to determine sugar constituents. The content of methanol-water extract ranged from 3.7 to 7.8% based on dried wood. After a 4-5 yr duration of heartwood formation in the sapwood, monosaccharide and alditol fractions doubly increased. This was followed by almost five times the content of cyclitols. In a radial variation, the content of major monosaccharides including fructose, glucose, mannose and xylose decreased from sapwood to heartwood, while arabinose, galactose, and sucrose in the age 5 years were only found in the sapwood. Meanwhile, the main content of cyclitols and alditols (arabitol) significantly decreased from sapwood to heartwood. The main monosaccharides and disaccharides represented by sucrose played a key role in the process of heartwood formation. Further studies are required to investigate the phenolic and lipophilic components as both are involved in heartwood formation. In addition, similar studies on alditol and cyclitol regarding their role in tropical wood are necessary. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6HPLC of Formula: 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Identification of a series of PPARγ/δ dual agonists via solid-Phase parallel synthesis was written by Liu, Kevin G.;Lambert, Millard H.;Leesnitzer, Lisa M.;Oliver, William;Ott, Ronda J.;Plunket, Kelli D.;Stuart, Ludwig W.;Brown, Peter J.;Willson, Timothy M.;Sternbach, Daniel D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.Name: 6-Methyl-2-pyridinemethanol This article mentions the following:

The authors have developed a general solid-phase synthesis for identification of PPAR (peroxisome proliferator-activated receptors) ligands. Synthesis of a 480-member library led to the identification of a potent PPARγ/δ dual agonist 23. Compound I showed good plasma exposure in rats and demonstrated antihyperglycemic and antihyperlipidemic efficacy in diabetic fatty Zucker rats. Compounds with PPARγ/δ dual activity may be useful in the treatment of metabolic syndrome X. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Name: 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: 6-Methyl-2-pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The versatile, efficient, and stereoselective self-assembly of transition-metal helicates by using hydrogen-bonds was written by Telfer, Shane G.;Kuroda, Reiko. And the article was included in Chemistry – A European Journal in 2005.Electric Literature of C7H9NO This article mentions the following:

A diverse range of dinuclear double-stranded helicates in which the ligand strand is built up by using H-bonding was synthesized. The helicates, formulated as [Co₂(L)₂(L-H)₂X₂], readily self-assemble from a mixture of a suitable pyridine-alc. compound (L; for example, 6-methylpyridine-2-methanol, 1), and a CoX₂ salt in the presence of base. Nine such helicates were characterized by x-ray crystallog. For helicates derived from the same pyridine-alc. precursor, a remarkable regularity was found for both the mol. structure and the crystal packing arrangements, regardless of the nature of the ancillary ligand (X). A notable exception was observed in the solid-state structure of [Co₂(1)₂(1-H)₂(NCS)₂] for which intermol. nonbonded contacts between the S atoms (S···S = 3.21 Å) give 1-dimensional chains. Helicates derived from (R)-6-methylpyridine-2-methanol (2) are soluble in solvents such as MeCN and CH₂Cl₂, and their self-assembly could be monitored in solution by ¹H NMR, UV/visible, and CD titrations No intermediate complexes form in a significant concentration at any point throughout these titrations The global thermodn. stability constant of [Co₂(2)₂(2-H)₂(NO₃)₂] was calculated from spectrophotometric data to be logβ = 8.9(8). The stereoisomerism of these helicates was studied in some detail and the self-assembly process is highly stereoselective. The chirality of the ligand precursors can control the absolute configuration of the metal centers and thus the overall helicity of the dinuclear assemblies. Also, the enantiomers of rac-6-methylpyridine-2-methanol (3) undergo a self-recognition process to form exclusively homochiral helicates in which the four pyridine-alc. units possess the same chirality. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Electric Literature of C7H9NO).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Electric Literature of C7H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Behavior of glycosylated monoterpenes, C₁₃-norisoprenoids, and benzenoids in Vitis vinifera cv. Riesling during ripening and following hedging was written by Ryona, Imelda;Sacks, Gavin L.. And the article was included in ACS Symposium Series in 2013.Formula: C10H22O3 This article mentions the following:

Many key odorants in wines cannot be detected in winegrapes (V. vinifera) because they are present as glycosides. Although several studies on grape glycosides have been reported, the correlation of different glycoside classes with each other during ripening is not clear. Addnl., the effects of late season hedging on grape glycoside accumulation have not been studied. We characterized three major glycoside classes in Riesling grapes grown in New York State during the 2009 and 2010 seasons throughout ripening. Most glycosylated monoterpenes and C₁₃-norisoprenoids increased post-veraison, but the onset of accumulation was one to two weeks earlier for most C₁₃-norisoprenoids (>50% of maximum prior to 23 days post-veraison, ‘dpv’) than for monoterpenes (after 30 dpv). Within each aroma class, most monoterpene and C₁₃-norisoprenoid aglycons were highly correlated (r>0.9). The behavior of benzenoids was not consistent during the two seasons. Finally, late-season hedging of Riesling vines did not significantly affect the concentrations of most glycosylated volatiles at harvest. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Formula: C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fe(III)-catalyzed trityl benzyl ether formation and disproportionation cascade reactions to yield benzaldehydes was written by Wang, Xiaoyu;Du, Chuan;Shi, Hui;Pang, Yadong;Jin, Shengfei;Hou, Yuqian;Wang, Yanshi;Peng, Xiaoshi;Xiao, Jianyong;Liu, Yang;Liu, Yongxiang;Cheng, Maosheng. And the article was included in Tetrahedron in 2015.Formula: C7H6BrClO This article mentions the following:

During investigating water-compatible Lewis acids catalyzed etherifications using alcs. as alkylating reagents directly, Fe(III)-catalyzed trityl benzyl ether formations irradiated by microwave are developed. Then an in situ trityl benzyl ether formation and disproportionation cascade reaction was achieved to yield the benzaldehyde products with good functional group tolerances under neat conditions at relative higher temperatures The substituent effects of the substrates on the etherification and disproportionation were explored by changing the substitutions on benzyl alcs. and triarylmethanols using chem. kinetic plots methods and the mechanism of the transformation was studied by crossover experiments The etherification and disproportionation cascade process could be conveniently scaled up in laboratory without losing much efficiency. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8Formula: C7H6BrClO).

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C7H6BrClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts