Month: January 2023

Mild and convenient oxidation of aromatic heterocyclic primary alcohols by 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium perchlorate was written by Kernag, Casey A.;Bobbitt, James M.;McGrath, Dominic V.. And the article was included in Tetrahedron Letters in 1999.Quality Control of 6-Methyl-2-pyridinemethanol This article mentions the following:

Hydroxymethyl-substituted aromatic heterocycles, including pyridines, furans, and thiophenes, are oxidized to the corresponding aldehydes in excellent yields by 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium perchlorate with minimal workup. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Quality Control of 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of 6-Methyl-2-pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A highly ordered chiral inorganic mesoporous material used as stationary phase for high-resolution gas chromatographic separations was written by Li, Yan-Xia;Fu, Shi-Guo;Zhang, Jun-Hui;Xie, Sheng-Ming;Li, Lang;He, Yu-Yu;Zi, Min;Yuan, Li-Ming. And the article was included in Journal of Chromatography A in 2018.Computed Properties of C4H11NO This article mentions the following:

A highly ordered chiral mesoporous silica-coated capillary column has been used for high-resolution gas chromatog. separations The column has excellent selectivity, not only for the separation of isomers, polycyclic aromatic hydrocarbons, linear alkanes, long chain alkanes, Grob’s test mixture and aromatic hydrocarbons, but also for the resolution of different classes of chiral compounds Addnl., the column exhibits high column efficiency, excellent temperature resistance, and anal. times are short. This is the first report of a highly ordered chiral inorganic mesoporous silica used in separation science. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Computed Properties of C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Computed Properties of C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hard gelatine capsules: DEM supported experimental study of particle arrangement effect on properties and vibrational transport behavior was written by Jezerska, Lucie;Prokes, Rostislav;Gelnar, Daniel;Zegzulka, Jiri. And the article was included in Powder Technology in 2022.Safety of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate This article mentions the following:

Hard gelatine capsules remain a relevant dosage form for today′s pharmaceutical manufacturing A wide range of color and print options supports marketing, brand image and patient loyalty. However, the filling of these capsules with various modern dosage forms and combinations thereof may affect their further processing. Therefore, a detailed study was carried out to assess the effect of mech.-phys. properties on the behavior of differently filled hard gelatine capsules. Capsules filled with powder, free or fixed particles presenting drug microforms and also hard gelatine capsules themselves were evaluated. Basic mech.-phys. characterization was performed on all samples. Furthermore, their transport on the vibrating conveyor was assessed and simulated using DEM. The results showed a significant influence mainly by the degree of capsule imbalance, i.e., the arrangement of particles in the capsule. It was found that the hard gelatine capsules showed an average of 15.6° lower values for the effective angle of internal friction compared to the powd. vitamin mixture, and in parallel, an average of 14.7° lower values for the static angle of repose were also recorded. The results of the experiments on the vibrating conveyor at a frequency setting of 15 Hz showed three times longer transport time for the vitamin mixture compared to the capsules. Increasing the frequency evened out these differences. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Safety of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ultrafine Pt nanoparticles supported on a dendrimer containing thiol groups: an efficient catalyst for the synthesis of benzimidazoles and benzothiazoles from benzyl alcohol derivatives in water was written by Nori, Zahra Zamani;Landarani-Isfahani, Amir;Bahadori, Mehrnaz;Moghadam, Majid;Mirkhani, Valiollah;Tangestaninejad, Shahram;Mohammadpoor-Baltork, Iraj. And the article was included in RSC Advances in 2020.Recommanded Product: (2,4-Dichlorophenyl)methanol This article mentions the following:

A novel and unique platform was prepared based on a dendrimer containing thiol groups supported on nanosilica (nSTDP), and ultrafine platinum nanoparticles were synthesized and immobilized on the thiol decorated branches of nSTPD. The new catalyst, (Ptnp@nSTDP), was characterized by different techniques such as FE-SEM, TEM, ICP, XPS and DR UV-vis. This heterogeneous catalyst presented an outstanding performance for the synthesis of benzimidazole and benzothiazole derivatives through a reaction between benzyl alc. derivatives and 2-aminothiophenol or 1,2-phenylenediamine. No requirement for the pre-reduction of catalysts and using water as a green solvent make it an individual catalyst for these reactions. Furthermore, the catalyst can be easily recovered and reused five consecutive times in the production of benzimidazoles and benzothiazoles without significant leaching of Pt and loss of its activity which illustrated the chem. stability of the catalyst during the reaction. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Recommanded Product: (2,4-Dichlorophenyl)methanol).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: (2,4-Dichlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selective estrogen receptor modulators: cannabinoid receptor inverse agonists with differential CB1 and CB2 selectivity was written by Franks, Lirit N.;Ford, Benjamin M.;Prather, Paul L.. And the article was included in Frontiers in Pharmacology in 2016.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

Selective estrogen receptor modulators (SERMs) are used to treat estrogen receptor (ER)-pos. breast cancer and osteoporosis. Interestingly, tamoxifen and newer classes of SERMs also exhibit cytotoxic effects in cancers devoid of ERs, indicating a non-estrogenic mechanism of action. Indicative of a potential ER-independent target, reports demonstrate that tamoxifen binds to cannabinoid receptors (CBRs) with affinity in the low mM range and acts as an inverse agonist. To identify cannabinoids with improved pharmacol. properties relative to tamoxifen, and further investigate the use of different SERM scaffolds for future cannabinoid drug development, this study characterized the affinity and activity of SERMs in newer structural classes at CBRs. Fourteen SERMs from five structurally distinct classes were screened for binding to human CBRs. Compounds from four of five SERM classes examined bound to CBRs. Subsequent studies fully characterized CBR affinity and activity of one compound from each class. Ospemifine (a triphenylethylene) selectively bound to CB1Rs, while bazedoxifine (an indole) bound to CB2Rs with highest affinity. Nafoxidine (a tetrahydronaphthalene) and raloxifene (RAL; a benzothiaphene) bound to CB1 and CB2Rs non-selectively. All four compounds acted as inverse agonists at CB1 and CB2Rs, reducing basal G-protein activity with IC₅₀ values in the nM to low mM range. Ospemifine, bazedoxifene and RAL also acted as inverse agonists to elevate basal intracellular cAMP levels in intact CHO-hCB2 cells. The four SERMs examined also acted as CB1 and CB2R antagonists in the cAMP assay, producing rightward shifts in the concentration-effect curve of the CBR agonist CP-55,940. In conclusion, newer classes of SERMs exhibit improved pharmacol. characteristics (e.g., in CBR affinity and selectivity) relative to initial studies with tamoxifen, and thus suggest that different SERM scaffolds may be useful for development of safe and selective drugs acting via CBRs. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Removing the Obstacle to (-)-Menthol Biosynthesis by Building a Microbial Cell Factory of (+)-cis-Isopulegone from (-)-Limonene was written by Shou, Chao;Zheng, Yu-Cong;Zhan, Jing-Ru;Li, Chun-Xiu;Xu, Jian-He. And the article was included in ChemSusChem in 2022.Recommanded Product: 2216-51-5 This article mentions the following:

Microbial synthesis of plant-based (-)-menthol is of great interest because of its high demand (≈30 kiloton per yr) as well as unique odor and cooling characteristics. However, this remains a great challenge due to the yet unfilled gap between (-)-limonene and (+)-cis-isopulegone. Herein, the first artificial and effective system was developed for (+)-cis-isopulegone biosynthesis from (-)-limonene by recruiting two bacterial enzymes to replace their inefficient counterparts from Mentha piperita, limonene-3-hydroxylase, and isopiperitenol dehydrogenase. A cofactor self-regenerative recombinant Escherichia coli strain was constructed by introducing a formate dehydrogenase for NADP (NADPH) regeneration and an engineered microbial isopiperitenol dehydrogenase. The production of (+)-cis-isopulegone (up to 281.2 mg L-1) was improved by 36 times compared with that of the initial strain. This work lays a reliable foundation for the microbial synthesis of (-)-menthol. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Recommanded Product: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Parts-per-million level loading organocatalysed enantioselective silylation of alcohols was written by Park, Sang Yeon;Lee, Ji-Woong;Song, Choong Eui. And the article was included in Nature Communications in 2015.Quality Control of (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

One p.p.m. loading of a simple 1,1′-bi-2-naphthol-based organocatalyst, I, was enough to achieve highly enantioselective silylation reactions of alcs. RCH(OH)R¹ (R = 4-H₃CC₆H₄, 3-F₃CC₆H₄, naphth-1-yl, etc.; R¹ = CH₃; R = Ph, R¹ = HC=CHC₆H₅). The unprecedented TONs and excellent enantioselectivity are ascribed to the robustness of the catalyst and systematic cooperative hydrogen-bonding organocatalysis in a densely confined chiral space. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Quality Control of (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vinylation of Aldehydes Using Mn/Cr Alloy and a N₄-Ligand/Ni^II-Catalyst was written by Harnying, Wacharee;Berkessel, Albrecht. And the article was included in Chemistry – A European Journal in 2015.Recommanded Product: 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine This article mentions the following:

An efficient and practical protocol for the Cr/Ni-catalyzed vinylation of aldehydes, based on the use of Mn/Cr alloy (ca. 10 % Cr) and TMSCl is reported. In the presence of NiCl₂ (0.3 mol %) and 6,6′-diacetyl-2,2′-bipyridine bis(2,6-diisopropylphenyl)imine as an N₄-chelating ligand (1 mol%), the vinylations proceed smoothly at room temperature The presence of catalytic amounts of MeOH and LiOAc as additives was found to further promote the efficiency of the catalytic system, even in the absence of the ligand. Detailed reaction monitoring revealed that LiOAc accelerates the product alc. silylation, thus increasing the turnover rate. In the experiment, the researchers used many compounds, for example, 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9Recommanded Product: 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine).

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An alternate methodology for studying diffusion and elution kinetics of dimethacrylate monomers through dentinal tubules was written by Durner, Juergen;Schrickel, Klaus;Watts, David C.;Becker, Marc;Hickel, Reinhard;Draenert, Miriam E.. And the article was included in Dental Materials in 2020.Category: alcohols-buliding-blocks This article mentions the following:

Ethoxylated bisphenol A dimethacrylate (bisEMA) is a base monomer in several dental resin composites. It was the main aim of the present study to determine if bisEMA can reach the dental pulp by generally passive diffusion through the coronal dentinal tubules stimulated via eluent liquids surrounding the root structures only.In 20 human third molar teeth, standard Class-I occlusal cavities were prepared and provided either with an adhesive system alone or addnl. with a composite restoration, according to the instructions of the manufacturer. The teeth were placed in an elution chamber such that the elution media only came into contact with the tooth root/tooth base where they were incubated at 37°C for up to 7 d. Samples were taken after 1, 2, 4 and 7 d. Gas chromatog./mass spectrometry was used to identify bisEMA and other monomers in ethanol/water (3:1) and aqueous eluates.bisEMA was only found in ethanol/water eluates, where the teeth had received a composite restoration. Traces of bisEMA with up to three ethylene oxide units could be detected in these eluates. Depending on the dentin thickness, different elution kinetics of bisEMA were determined Regardless of the treatment of teeth, triethylene glycol dimethacrylate (TEGDMA) and tetraethylene glycol dimethacrylate (TEEGDMA) were found in ethanolic/aqueous eluates in equal amounts Most TEGDMA and TEEGDMA diffused through the dentin within the first 24 h.Depending on the dentin layer thickness, bisEMA was released for varied time periods, resulting in varied concentrations and exposure times for the different cells of the dental pulp. The concentrations of TEGDMA and TEEGDMA were greatest for cells of the dental pulp within the first 24 h. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Category: alcohols-buliding-blocks).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of combined carnosine and ultra-high pressure on the inhibition of fishy off-odor of snakehead fillets and the possible mechanism was written by Sun, Liangge;Lv, Jingxiu;Liu, Yu;Zang, Mingwu;Li, Pengpeng;Wang, Daoying;Zhu, Yongzhi;Xu, Weimin. And the article was included in Food Chemistry in 2022.Formula: C8H16O This article mentions the following:

The effects of combined application of ultra-high pressure (300 Mpa, 900 s) and carnosine on the inhibition of fishy off-odor from snakehead meat were investigated. Results showed that the combination effectively inhibited the formation of fishy volatile organic compounds (VOCs) and trimethylamine (TMA-N). Further studies demonstrated that the reduction of VOCs was mainly due to the inhibition of lipids oxidation based on the antioxidant activity of carnosine and the inactivation of lipoxygenase by UHP. Moreover, the reduction of TMA-N was mainly attributed to the ability of UHP processing to reduce bacterial load, which also extended the shelf-life of snakehead fillets by ∼ 6 days and retarded the production of TVB-N. Addnl., the combined application allowed a better retention of pH, color, and textural quality of the fillets compared with the control. Therefore, the current combination is a promising technique in fishy off-odor removing and better preservation of snakehead meat. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Formula: C8H16O).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C8H16O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts