Month: January 2023

Steric effects in the copper(II) chelates of 2-pyridyl alcohols was written by Lane, T. J.;Kandathil, A. J.;Rosalie, S. M.. And the article was included in Inorganic Chemistry in 1964.Computed Properties of C7H9NO This article mentions the following:

The acid dissociation constants of 2-pyridylcarbinol, 6-methyl-2-pyridylcarbinol, 2-(β-hydroxyethyl)pyridine, and 2-(β-hydroxyethyl)-6-methylpyridine and the stability constants of the Cu(II) chelates of these ligands were determined by the Calvin-Bjerrum (C. and Wilson, CA 40,285⁸; B., Metal Ammine Formation in Aqueous Solution: Theory of the Reversible Step Reactions, 1941(CA 35, 6206³)) potentiometric titration technique in 50 volume % 1,4-dioxane-water at 0, 15, and 25°. Enthalpy values were determined from direct calorimetric measurements as well as from the temperature dependence of the formation constants The results of the study show that the presence of the Me group in the 6-position decreases enthalpy and increases entropy, and the increase in entropy is not large enough to counteract the effects of steric hindrance. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Computed Properties of C7H9NO).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Computed Properties of C7H9NO

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vapor-phase hydrogenolysis of glycerol to value-added 1,2-propanediol over copper-nickel bimetallic catalysts supported on activated carbon was written by Kashif, Mohammad;Thangarasu, Sadhasivam;Oh, Tae Hwan;Biswas, Prakash;Kang, Dohyung. And the article was included in Korean Journal of Chemical Engineering in 2022.SDS of cas: 57-55-6 This article mentions the following:

In the production of biodiesel, a sustainable energy alternative to fossil fuel, surplus glycerol, is generated as a byproduct. Valorization of excess glycerol is the most promising approach for rendering the biodiesel sector fiscally practical. Herein, copper and nickel monometallic and bimetallic catalysts supported over activated carbon were developed using the incipient wetness impregnation technique for the hydrogenolysis of vapor-phase glycerol to 1,2-propanediol (1,2-PDO) at a pressure of 0.75 MPa and temperature of 220°C. The catalysts were characterized by Brunauer-Emmett-Teller, X-ray diffraction, H₂-temperature-programmed reduction, NH₃-temperature-programmed desorption, XPS, and SEM analyses. The bimetallic catalysts afforded higher product yields than the monometallic catalysts did in glycerol hydrogenolysis. Cu-Ni(1:1)/AC gave the maximum yield of 1,2-PDO (87.3%), with high glycerol conversion (95.7%) under the previously mentioned reaction conditions, with a comparatively low molar ratio of hydrogen to glycerol (54.6). The strong copper-nickel synergy, smaller crystallite size, and high acid strength of Cu-Ni(1:1)/AC account for this superior performance. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6SDS of cas: 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Total Synthesis and Structure Assignment of Saptomycin H was written by Shimura, Jun;Ando, Yoshio;Ohmori, Ken;Suzuki, Keisuke. And the article was included in Organic Letters in 2022.SDS of cas: 2216-51-5 This article mentions the following:

We report herein the first total synthesis of saptomycin H, by which the unidentified absolute stereochem. of the oxiranyl side chain has been determined as 14R, 16S. The keys include a concise assembly of three units, anthrone, sugar and side chain and AZADOL-mediated 6-endo selective pyranone (A-ring) formation. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

N-Arylazetidines: Preparation through Anionic Ring Closure was written by Quinodoz, Pierre;Drouillat, Bruno;Wright, Karen;Marrot, Jerome;Couty, Francois. And the article was included in Journal of Organic Chemistry in 2016.Synthetic Route of C4H11NO This article mentions the following:

We report herein an efficient synthesis of diversely substituted N-aryl-2-cyanoazetidines based on an anionic ring-closure reaction. These compounds can be prepared from β-amino alcs. in enantiomerically pure form through a three-step sequence involving (i) copper-catalyzed N-arylation, (ii) N-cyanomethylation of the secondary aniline, and (iii) one-pot mesylation followed by ring closure induced by a base. This high-yielding sequence gives access to azetidines with a predictable and adjustable substitution pattern and also with predictable diastereoselectivity. These compounds are susceptible to multiple further derivatizations through Suzuki coupling or nitrile transformation, thus appearing as valuable new scaffolds for medicinal chem. Their rigid shape, featuring an almost planar N-arylamine and a planar four-membered ring, was revealed by both AM1 calculations and X-ray crystallog. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Synthetic Route of C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Synthetic Route of C4H11NO

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Alcohol – Wikipedia,
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Ospemifene for the treatment of dyspareunia associated with vulvar and vaginal atrophy: potential benefits in bone and breast was written by Soe, Lin H.;Wurz, Gregory T.;Kao, Chiao-Jung;DeGregorio, Michael W.. And the article was included in International Journal of Women’s Health in 2013.Recommanded Product: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

Ospemifene is a selective estrogen receptor modulator (SERM), or estrogen receptor agonist/antagonist, that was recently approved by the US Food and Drug Administration for the treatment of dyspareunia associated with vulvar and vaginal atrophy, a chronic condition that affects up to 60% of postmenopausal women. Ospemifene is the first and only nonestrogen compound approved for this indication. Compared with other approved SERMs, such as tamoxifen, toremifene, bazedoxifene and raloxifene, the estrogen-like effects of ospemifene in the vaginal epithelium are unique. This review first discusses the rationale for developing ospemifene, including its mechanism of action and then focuses on the clin. development of ospemifene for the treatment of dyspareunia associated with vulvar and vaginal atrophy. Included are discussions of the effects of ospemifene on the endometrium, serum lipids, coagulation markers, bone and breast cancer. In conclusion, ospemifene is a SERM with a unique estrogen agonist/antagonist tissue profile that was recently approved in the US for the treatment of dyspareunia associated with vulvar and vaginal atrophy in postmenopausal women. Ospemifene warrants further clin. investigation for the treatment and prevention of osteoporosis and breast cancer. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Recommanded Product: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Heterogeneous Catalysis for Oxidation of Alcohol via 1-Methyl-2-azaadamanane N-oxyl Immobilized on Magnetic Polystyrene Nanosphere was written by Guo, Xiaqun;Li, Meichao;Wang, Jianli;Li, Chunmei;Hu, Xinquan;Jin, Liqun;Sun, Nan;Hu, Baoxiang;Shen, Zhenlu. And the article was included in ChemistrySelect in 2022.Category: alcohols-buliding-blocks This article mentions the following:

A highly promising heterogeneous strategy was describedn in which a catalytic amount of 1-methyl-2-azaadamanane N-oxyl immobilized on magnetic polystyrene nanosphere (1-Me-AZADO/MPNs) was used and a series of carbonyl compounds were obtained from various alcs. in 73-99% isolated yields and high selectivity (>99%) under Anelli conditions, thus offering a greener and more convenient methods in the synthesis of carbonyl compounds The attractive features of convenient magnetic separation (within seconds), good recyclability (up to 20 runs) and fast reaction rates (5-20 min) were very efficient to improve the utility of azaadamantane-type-nitroxyl radicals in the oxygenation. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Category: alcohols-buliding-blocks).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Convenient synthesis of symmetrical azines from alcohols and hydrazine catalyzed by ruthenium(II) hydrazone complex in air was written by Gayathri, S.;Viswanathamurthi, P.;Naveen, K.;Murugan, K.. And the article was included in Inorganica Chimica Acta in 2022.Application of 873-76-7 This article mentions the following:

New ruthenium(II) complexes were synthesized from the reaction of ligands namely 10-(2-(benzothiazol-2-yl)hydrazano)phenanthren-9(10H)-one (BTPQ), I or 10-(2-(quinolin-2-yl)hydrazano)phenanthren-9(10H)-one (QHPQ), II with [RuHCl(CO)(EPh₃)₃] (E = P or As) under reflux. The formation of the complexes was confirmed by anal. and various spectral methods including single crystal XRD anal. The synthesized complexes were applied as catalysts for the synthesis of sym. azines from alcs. and hydrazine hydrate under air. Different substituents in alcs. were well tolerated and wide spectrum of azines were synthesized in good to excellent yields using 1 mol % of catalyst loading. The aerobic catalytic reaction released environmentally benign H₂O as the only byproduct. Moreover, a plausible mechanism was provided for the Ru-catalyzed azine synthesis. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Application of 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tuning biodegradable hydrogel properties via synthesis procedure was written by Hawkins, Ashley M.;Tolbert, Melanie E.;Newton, Brittany;Milbrandt, Todd A.;Puleo, David A.;Hilt, J. Zach. And the article was included in Polymer in 2013.Safety of Diethyleneglycoldiacrylate This article mentions the following:

Biodegradable hydrogels have become a rapidly expanding area of research for biomedical applications. Poly(β-amino ester) (PBAE) biodegradable hydrogels, in particular, have been studied extensively because of the ease of synthesis and range of properties exhibited. In this work, PBAE macromers were created with poly(ethylene glycol) diacrylate (PEGDA), diethylene glycol diacrylate (DEGDA), and isobutylamine. Many methods have been presented that allow control over the resulting hydrogel behavior. Here, properties were varied by combining multiple diacrylate components in the macromer synthesis step (single macromer (SM)) or through the combination of multiple macromers prior to polymerization (double macromer (DM)). The exhibited properties are a result of the hydrophilic/hydrophobic contributions of the different diacrylate mols. to the macromer. The SM systems exhibited linear degradation profiles, the rate of degradation increased as the PEGDA concentration increased. DM systems exhibited a multiphase degradation profile as a result of the combination of macromers with different hydrophilic properties. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Safety of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of Diethyleneglycoldiacrylate

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selective Palladium(II)-Catalyzed Carbonylation of Methylene β-C-H Bonds in Aliphatic Amines was written by Cabrera-Pardo, Jaime R.;Trowbridge, Aaron;Nappi, Manuel;Ozaki, Kyohei;Gaunt, Matthew J.. And the article was included in Angewandte Chemie, International Edition in 2017.Product Details of 5856-63-3 This article mentions the following:

Palladium(II)-catalyzed C-H carbonylation reactions of methylene C-H bonds in secondary aliphatic amines lead to the formation of trans-disubstituted β-lactams in excellent yields and selectivities. The generality of the C-H carbonylation process is aided by the action of xantphos-based ligands and is important in securing good yields for the β-lactam products. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Product Details of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discrimination of genetic and geographical groups of grape varieties (Vitis vinifera L.) based on their polyphenolic profiles was written by Sikuten, Iva;Stambuk, Petra;Tomaz, Ivana;Marchal, Cecile;Kontic, Jasminka Karoglan;Lacombe, Thierry;Maletic, Edi;Preiner, Darko. And the article was included in Journal of Food Composition and Analysis in 2021.Recommanded Product: 10083-24-6 This article mentions the following:

Relevant aspect of wine geog. origin is related to grapevine varieties used for wine production in specific wine country or region. The grapevine germplasm is highly variable and classified into geog. groups. These classifications were recently confirmed using genetic studies, and further classified varieties into geog.-genetic (GEN-GEO) groups. Polyphenolic compounds are important secondary metabolites in grapes and have an important impact on wine quality and sensory properties. The aim of this research was to investigate the polyphenolic profiles of 50 grape varieties from different GEN-GEO groups. The groups were C2 (varieties from Italy and France), C7 (varieties from Croatia), C8 (varieties from Spain and Portugal). Polyphenolic compounds analyzed belonged to the classes of anthocyanins, flavan-3-ols, flavonols, phenolic acids, and stilbenes. The most abundant classes of polyphenols were anthocyanins, followed by flavan-3-ols and flavonols. Using discriminant anal., the genetic-geog. groups were clearly separated based on their polyphenolic profiles, with all classes of compounds contributing to discrimination. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 10083-24-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts