A rapid and practical catalytic esterification for the preparation of caffeic acid esters was written by Xie, Dongsheng;Yang, Fengzhi;Xie, Jin;Zhang, Man;Liu, Wenlu;Fu, Lei. And the article was included in Journal of Chemical Research in 2014.Name: 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:
A convenient and practical catalytic method for the preparation of caffeic acid esters is reported. This esterification was carried out with high efficiency in the presence of ytterbium triflate in nitromethane without any other auxiliary reagents. The wide scope of application and especially the higher reactivity and more convenient procedure than previous methods make it a valuable application for the synthesis of caffeic acid esters and other cinnamic acid esters. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Name: 2-(4-(Trifluoromethyl)phenyl)ethanol).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: 2-(4-(Trifluoromethyl)phenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts