Catalyst-Free α-Alkylation-α-Hydroxylation of Oxindole with Alcohols was written by Wu, Siwei;Song, Wei;Zhu, Runyu;Hu, Jingwen;Zhao, Lin;Li, Zheyao;Yu, Xinhong;Xia, Chengcai;Zhao, Jianhong. And the article was included in Journal of Organic Chemistry in 2022.Application of 873-76-7 This article mentions the following:
A green and economical protocol for the synthesis of 3-alkyl-3-hydroxyoxindoles I [R1 = H, 6-Cl, 6-Br, etc.; R2 = Ph, 2-ClC6H4, 2-pyridyl, etc.] was developed for the first time via α-alkylation-α-hydroxylation of oxindole with aryl alcs. without using any transition-metal catalysts in yields of 29-93%. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Application of 873-76-7).
(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 873-76-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts