Synthesis of cinnamic acid ester derivatives with antiproliferative and antimetastatic activities on murine melanoma cells was written by Vale, Juliana Alves do;Rodrigues, Michelle Peixoto;Lima, Angela Maria Almeida;Santiago, Samira Soares;Lima, Graziela Domingues de Almeida;Almeida, Alisson Andrade;Oliveira, Leandro Licursi de;Bressan, Gustavo Costa;Teixeira, Robson Ricardo;Machado-Neves, Mariana. And the article was included in Biomedicine & Pharmacotherapy in 2022.Application of 873-76-7 This article mentions the following:
The synthesis of seventeen compounds I [R = Bn, Ph, 4-ClC6H4CH2, etc.] was derived from cinnamic acid and their bioactivity evaluation against melanoma cells. The compound Ph 2,3-dibromo-3-phenylpropanoate II was the most effective against murine B16-F10 cells, as observed in cytotoxicity and cell migration assays. Simultaneously, this compound showed low cytotoxic activity on non-tumor cells. At the highest concentration, the compound II was able to trigger apoptosis, whereas at lower concentrations, it affected the cell cycle and melanoma cell proliferation. Furthermore, cinnamate II impaired cell invasion, adhesion, colonization, and actin polymerization In conclusion, these results highlight the antiproliferative and antimetastatic potential of cinnamic acid derivatives on melanoma. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Application of 873-76-7).
(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 873-76-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts