Light-Triggered, Self-Immolative Nucleic Acid-Drug Nanostructures was written by Tan, Xuyu;Li, Ben B.;Lu, Xueguang;Jia, Fei;Santori, Clarissa;Menon, Priyanka;Li, Hui;Zhang, Bohan;Zhao, Jean J.;Zhang, Ke. And the article was included in Journal of the American Chemical Society in 2015.Synthetic Route of C7H7NO4 This article mentions the following:
The simultaneous intracellular delivery of multiple types of payloads, such as hydrophobic drugs and nucleic acids, typically requires complex carrier systems. Herein, we demonstrate a self-deliverable form of nucleic acid-drug nanostructure that is composed almost entirely of payload mols. Upon light activation, the nanostructure sheds the nucleic acid shell, while the core, which consists of prodrug mols., disintegrates via an irreversible self-immolative process, releasing free drug mols. and small mol. fragments. We demonstrate that the nanostructures exhibit enhanced stability against DNase I compared with free DNA, and that the model drug (camptothecin) released exhibits similar efficacy as free, unmodified drugs toward cancer cells. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Synthetic Route of C7H7NO4).
3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C7H7NO4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts