Unclicking the “click”: a photo-releasable 1,2,3-triazole in block copolymers was written by Sterner, Elizabeth S.;Tsai, Tsung-Han;Coughlin, E. Bryan. And the article was included in PMSE Preprints in 2010.Quality Control of 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:
We have synthesized an o-nitrobenzyl triazole and demonstrated its photo-release of the free triazole both in a small mol. analog and within a polystyrene-b-poly(vinyl acetate) copolymer. This robust linker was created using popular (2+3) cycloaddition of an azide and alkyne to make an ATRP macroinitiator that was used to polymerize the styrene. Our results indicate the synthesis of the macroinitiator was quant., and that the ATRP initiating site was conserved through the click transformation. Irradiation of the copolymer caused cleavage into its component blocks. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Quality Control of 3-(Hydroxymethyl)-4-nitrophenol).
3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of 3-(Hydroxymethyl)-4-nitrophenol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts