Borane evolution and its application to organic synthesis using the phase-vanishing method was written by Soga, Nene;Yoshiki, Tomo;Sato, Aoi;Kawamoto, Takuji;Ryu, Ilhyong;Matsubara, Hiroshi. And the article was included in Tetrahedron Letters in 2021.Safety of 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:
Although borane is a useful reagent, it is difficult to handle. In this study, borane was generated in situ from NaBH4 or nBu4NBH4 with several oxidants (H2SO4, I2, or EtI) using a phase-vanishing (PV) method using a mixture of a fluorinated solvent (Galden HT-135, Galden HT-200, or FC-72) and a nonfluorinated solvent (DME or THF). The borane generated was directly reacted with alkenes, affording the desired alcs. in good yields after oxidation with H2O2 under basic conditions. The selective reduction of carboxylic acids with the evolved borane was examined The organoboranes generated by the PV method successfully underwent Suzuki-Miyaura coupling. Using this PV system, reactions with borane can be carried out easily and safely in a common test tube. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Safety of 2-(4-(Trifluoromethyl)phenyl)ethanol).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of 2-(4-(Trifluoromethyl)phenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts