Allyl 4-Chlorophenyl Sulfone as a Versatile 1,1-Synthon for Sequential α-Alkylation/Cobalt-Catalyzed Allylic Substitution was written by Sekino, Tomoyuki;Sato, Shunta;Kuwabara, Kazuki;Takizawa, Koji;Yoshino, Tatsuhiko;Kojima, Masahiro;Matsunaga, Shigeki. And the article was included in Synthesis in 2020.Name: 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:
Herein, allyl 4-chlorophenyl sulfone as a versatile linchpin for both base-mediated α-derivatization and subsequent cobalt-catalyzed allylic substitution was identified. The sequential transformations allow for highly regioselective access to branched allylic substitution products with a variety of aliphatic side chains RCH2CH(CH=CH2)CH(C(O)OR1)2 (R = Me, phenylmethyl, 2-thiophen-2-ylmethyl, etc.; R1 = Me, Bn, 4-methylphenyl, etc.) and 2-(pent-1-en-3-yl)malononitrile. The photoredox-enabled cobalt catalysis is indispensable for achieving high yields and regioselectivity for the desulfonylative substitution in contrast to traditional metal-catalyzed protocols, which lead to inferior outcomes in the corresponding transformations. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Name: 2-(4-(Trifluoromethyl)phenyl)ethanol).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: 2-(4-(Trifluoromethyl)phenyl)ethanol
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Alcohols – Chemistry LibreTexts