Benzosultam Synthesis by Gold(I)-Catalyzed Ammonium Formation/Nucleophilic Substitution was written by Pertschi, Romain;Weibel, Jean-Marc;Pale, Patrick;Blanc, Aurelien. And the article was included in Organic Letters in 2019.Application of 142253-56-3 This article mentions the following:
The synthesis of benzosultams was achieved through a gold(I)-catalyzed ammonium formation strategy. Starting from easily available N-(2-alkynyl)phenylsulfonyl azetidine derivatives, a cyclization reaction generated a spiroammonium gold intermediate that was ring-opened by nucleophilic alc. or indole. This new methodol. is compatible with the large variation in the substrates and nucleophiles and gave benzosultams in high yield (18-98%, 20 examples). This strategy also gave benzosultam analogs via iododeauration and subsequent cross-coupling reactions. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3Application of 142253-56-3).
1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 142253-56-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts