Molecular encapsulation and bioactivity of gnetol, a resveratrol analogue, for use in foods was written by Navarro-Orcajada, Silvia;Conesa, Irene;Matencio, Adrian;Garcia-Carmona, Francisco;Lopez-Nicolas, Jose Manuel. And the article was included in Journal of the Science of Food and Agriculture in 2022.Reference of 10083-24-6 This article mentions the following:
Gnetol is a stilbene whose characterization and bioactivity have been poorly studied. It shares some bioactivities with its analog resveratrol, such as anti-inflammatory, anti-thrombotic, cardioprotective and anti-cancer activities. However, the low solubility of stilbenes may limit their potential applications in functional foods. Encapsulation in cyclodextrins could be a solution The antioxidant activity of gnetol was evaluated by 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation and ferric reducing antioxidant power methods (Trolox equivalent 13.48 μmol L-1 and 37.08 μmol L-1 resp. at the highest concentration) and it was higher than that of resveratrol, and depending on the method, similar or higher to that of oxyresveratrol. Spectrophotometric and spectrofluorimetric characterization of gnetol is published for the first time. Moreover, its water solubility was determined and improved almost threefold after its mol. encapsulation in cyclodextrins, as well as its stability after storage for a week. A physicochem. and computational study revealed that cyclodextrins complex gnetol in a 1:1 stoichiometry, with better affinity for like 2-hydroxypropyl-β-cyclodextrin (KF = 4542.90 ± 227.15 mol-1 L). Temperature and pH affected the encapsulation constants These results could increase interest of gnetol as an alternative to the most studied stilbene, resveratrol, as well as aid in the development of more stable inclusion complexes that improve its aqueous solubility and stability so that it can be incorporated into functional foods. 2022 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Reference of 10083-24-6).
(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 10083-24-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts