Photocleavable Supramolecular Polysaccharide Nanoparticles for Targeted Drug Release in Cancer Cells was written by Liu, Jiang-Hua;Wu, Xianjing;Zhang, Ying-Ming;Liu, Yu. And the article was included in Asian Journal of Organic Chemistry in 2018.COA of Formula: C7H7NO4 This article mentions the following:
Photocontrolled, targeted and biocompatible supramol. nanoparticles were constructed through the host-guest interactions of 2-nitrobenzyl ester-linked β-cyclodextrin and adamantane-grafted hyaluronic acid (HA). In this system, we used HA and 2-nitrobenzyl ester as targeting and photoresponsive groups, resp. Moreover, the introduction of β-cyclodextrin further enhanced the biocompatibility of the supramol. nanoparticles. Benefiting from the light-responsive capability of a 2-nitrobenzyl ester moiety, the hydrophobic anticancer drug camptothecin was loaded in the internal hydrophobic microenvironment of the supramol. nanoparticle and could be specifically released in the cancer cells. These results demonstrated that supramol. polysaccharide drug nanocarriers with targeting ability and intelligent light-stimulus responsiveness may have excellent potential in the clin. cancer treatments. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9COA of Formula: C7H7NO4).
3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.COA of Formula: C7H7NO4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts