Triarylethylene-indolin-2,3-dione molecular conjugates: design, synthesis, docking studies and anti-proliferation evaluation was written by Kumar, Sumit;Palma, Gabriella;Perumal, Shanen;Kaur, Mandeep;Singh-Pillay, Ashona;Raj, Raghu;Singh, Parvesh;Kumar, Vipan. And the article was included in RSC Advances in 2019.Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:
A series of 1H-1,2,3-triazole-linked ospemifene-isatin and O-methylated ospemifene-isatin conjugates I (R1 = H, Br, Cl, F; R2 = H, Br; X = C(O), 1,3-dioxolan-2-ylidene; Y = Me, 2-hydroxyethyl) were synthesized and assayed for their anti-proliferative activities against estrogen-responsive as well as estrogen-non-responsive cells. The non-cytotoxic conjugate I (R1 = R2 = Br; X = C(O); Y = 2-hydroxyethyl), with an optimal combination of bromo substituents at the C-5/C-7 positions of isatin, proved to be a promising hit with an IC50 value of 31.62μM against MCF-7 and 19.23μM against MDA-MB-231. The observed anti-proliferative activities of active conjugates I were further corroborated via docking studies carried out on estrogen receptor subtypes α and β. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).
(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts