Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists was written by Kanuma, Kosuke;Omodera, Katsunori;Nishiguchi, Mariko;Funakoshi, Takeo;Chaki, Shigeyuki;Nagase, Yasuko;Iida, Izumi;Yamaguchi, Jun-ichi;Semple, Graeme;Tran, Thuy-Anh;Sekiguchi, Yoshinori. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Quality Control of tert-Butyl (cis-4-(hydroxymethyl)cyclohexyl)carbamate This article mentions the following:
The optimization of the distance between two key pharmacophore features within our first hit compounds led to the identification of a new class of potent non-peptidic antagonists for the MCH-R1, based around 4-amino-2-cyclohexylaminoquinazolines. In particular, ATC0065, N 2-[cis-4-({2-[4-Bromo-2-(trifluoromethoxy)phenyl]ethyl}amino)cyclohexyl]-N4,N4-dimethylquinazoline-2,4-diamine dihydrochloride, bound with high affinity to the MCH-R1 (IC50 value of 16 nM) and showed good metabolic stability in liver microsomes from human and rat. In the experiment, the researchers used many compounds, for example, tert-Butyl (cis-4-(hydroxymethyl)cyclohexyl)carbamate (cas: 223131-01-9Quality Control of tert-Butyl (cis-4-(hydroxymethyl)cyclohexyl)carbamate).
tert-Butyl (cis-4-(hydroxymethyl)cyclohexyl)carbamate (cas: 223131-01-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of tert-Butyl (cis-4-(hydroxymethyl)cyclohexyl)carbamate
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts