One dimensional chemical shift modulated correlation spectroscopy of single-crystals was written by Iuliucci, Robbie J.;Grant, David M.. And the article was included in Solid State Nuclear Magnetic Resonance in 1996.Computed Properties of C6H14O6 This article mentions the following:
A simple 1-dimensional modulation method is presented for determining the spatial correlation of chem. shifts in two different single-crystal orientations. This proposed chem. shift modulated correlation (CSMC) spectroscopy uses a Jeener pulse sequence to give 1-dimensional spectra containing peaks that are amplitude modulated by the chem. shifts associated with the single-crystal’s evolution orientation. Conversely, the spectral frequencies in these 1-dimensional CSMC spectra designate the shifts in the crystal’s orientation during the detection period. By observing the amplitude modulation of these spectral frequencies, the spatial correlation between the two chem. environments can be established for a specific nucleus from a single 1-dimensional spectrum. The CSMC procedure finishes by acquiring a normal 1-dimensional static spectrum for the crystal oriented in the evolution direction, thereby providing very accurate evolution frequencies approximated by the amplitude modulation in the CSMC spectra. The CSMC method improves the time efficiency over both the traditional goniometer method and the 2-dimensional chem. shift-chem. shift correlation method, and therefore is beneficial for the study of samples with longer T1 values. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Computed Properties of C6H14O6).
(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C6H14O6
Referemce:
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Alcohols – Chemistry LibreTexts