Hydrogen-bond-assisted transition-metal-free catalytic transformation of amides to esters was written by Huang, Changyu;Li, Jinpeng;Wang, Jiaquan;Zheng, Qingshu;Li, Zhenhua;Tu, Tao. And the article was included in Science China: Chemistry in 2021.Quality Control of (2,4-Dichlorophenyl)methanol This article mentions the following:
A transition-metal-free hydrogen-bond-assisted esterification of amides RC(O)R1 (R = Ph, pyridin-4-yl, furan-2-yl, etc.; R1 = N-benzyl-N-tert-butoxycarbonylamino, amino, piperidin-1-yl, morpholin-4-yl, 2,3-dihydro-indol-1-yl, etc.), (4-benzoyl-piperazin-1-yl)-phenyl-methanone with only catalytic amount of base was developed. The proposed crucial role of hydrogen bonding for assisting esterification was supported by control experiments, d. functional theory (DFT) calculations and kinetic studies. Besides, broad substrate scopes and excellent functional groups tolerance, this base-catalyzed protocol complements the conventional transition-metal-catalyzed esterification of amides and provides a new pathway to catalytic cleavage of amide C-N bonds for organic synthesis and pharmaceutical industry. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Quality Control of (2,4-Dichlorophenyl)methanol).
(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of (2,4-Dichlorophenyl)methanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts