SulfoxFluor-enabled deoxyazidation of alcohols with NaN3 was written by Guo, Junkai;Wang, Xiu;Ni, Chuanfa;Wan, Xiaolong;Hu, Jinbo. And the article was included in Nature Communications in 2022.Recommanded Product: 128607-22-7 This article mentions the following:
Direct deoxyazidation of alcs. with NaN3 is a straightforward method for the synthesis of widely used alkyl azides in organic chem. A general and practical method for the preparation of alkyl azides from alcs. using NaN3 was developed. N-tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor) played an important role in this deoxyazidation process, which converted a broad range of alcs. into alkyl azides at room temperature The power of this deoxyazidation protocol was demonstrated by successful late-stage deoxyazidation of natural products and pharmaceutically relevant mols. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Recommanded Product: 128607-22-7).
(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 128607-22-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts