Derivatives of Amino Alcohols. I. Esters or Derivatives Acylated at the Oxygen was written by Fourneau, E.. And the article was included in Journal de Pharmacie et de Chimie in 1911.COA of Formula: C6H15NO This article mentions the following:
The esters of amino alcs. were prepared by mixing C6H6 solutions of the alcs. and the acid chlorides or bromides; the ester salts crystallize out almost immediately. With certain amino alcs. like diethylamino alcohol it was necessary to use no solvent in order to obtain the benzoate. Amino alcs. in which both functions are tertiary form esters with ClCO2Et, as with other acid chlorides, differing thus from the simple tertiary alcs. In this case the tertiary NH2 acts like pyridine in acylation. The amino alc. esters are nearly odorless liquids, which are more easily hydrolyzed by strong mineral acids than by alkalies. Derivatives of dimethylaminotrimethylcarbinol, Me2NCH2CMe2OH: Benzoate hydrochloride, cubes, m. 202° cinnamate hydrochloride, large plates, m. 208°, isovalerate hydrochloride, hygroscopic, unctuous leaflets, m. 125°. Derivatives of dimethylaminodimethylethylcarbinol: Benzoate, syrupy liquid, b13 150°, benzoate hydrochloride is stovaine, diethylcarbamate derivative, Me2NCH2C(O2CNEt2)MeEt, limpid liquid with peculiar odor b41 136°. Hydrochloride, hygroscopic needles from acetone, m. 142° (decompose), hydrobromide, sedative, needles, m. 148°, chloroaurate, long orange-red needles m. 98°, “valerate” derivative, b23 128°, very stable to alkalies, hydrochloride, anesthetic, hygroscopic, unctuous plates, m. 151°, hydrobromide, similar, but not hygroscopic, m. 126°. Bromovalerate hydrochloride, strongly anesthetic, fine needles, m. 158°. Diethylacetate hydrobromide, brilliant needles, m. 169°. Bromodiethylacetate hydrochloride, leaflets, m. 160°. Caproate derivative, b. (in vacuo) 152°. Hydrochloride, slender needles. The compounds with the aliphatic acids heavier than caproic are strongly modified by the acyl group and acquire the properties of soaps like the polypeptides of the higher aliphatic acids. Bromocaproate hydrochloride, slender hygroscopic needles, m. 130°. Aqueous solution gives lather. Bromo-oenanthylate hydrochloride, white leaflets, m. 128° anesthetic. Bromolaurate hydrochloride, slender needles. m. 99°. Aqueous solution gives lather. Dimethylaminomethyldiethylcarbinyl benzoate hydrochloride, Et2C(OBz)CH2NMe2.HCl, quadrangular plates, m. 180°. Dimethylaminodimethylpropylcarbinyl benzoate hydrochloride, isomeric with the preceding compound, brilliant needles, m. 146°. Dimethylaminodimethylisoamylcarbinyl benzoate hydrochloride, anesthetic, long needles, m. 142°. Chloroplatinate, m. 178°. Cinnamate hydrochloride, slender needles, m. 110°. Diethylaminodimethylethylcarbinyl benzoate hydrochloride, tufts of slender needles, m. 140°. In the experiment, the researchers used many compounds, for example, 1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9COA of Formula: C6H15NO).
1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.COA of Formula: C6H15NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts