Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists was written by Evindar, Ghotas;Satz, Alexander L.;Bernier, Sylvie G.;Kavarana, Malcolm J.;Doyle, Elisabeth;Lorusso, Jeanine;Taghizadeh, Nazbeh;Halley, Keith;Hutchings, Amy;Kelley, Michael S.;Wright, Albion D.;Saha, Ashis K.;Hannig, Gerhard;Morgan, Barry A.;Westlin, William F.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Electric Literature of C9H9F3O This article mentions the following:
In a search for potent and selective sphingosine-1-phosphate receptor agonists, the previously reported phenylamide and phenylimidazole scaffolds were utilized to explore extensive side-chain modifications to generate new mol. entities. A number of designed mols. demonstrated good selectivity and excellent in vitro and in vivo potency in both mouse and rat models. Oral administration of the lead mol. I (PPI-4667) demonstrated potent and dose-responsive lymphopenia. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Electric Literature of C9H9F3O).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C9H9F3O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts