New C2-symmetric chiral phosphinite ligands based on amino alcohol scaffolds and their use in the ruthenium-catalysed asymmetric transfer hydrogenation of aromatic ketones was written by Durap, Feyyaz;Aydemir, Murat;Elma, Duygu;Baysal, Akin;Turgut, Yilmaz. And the article was included in Comptes Rendus Chimie in 2013.SDS of cas: 5856-63-3 This article mentions the following:
Asym. transfer hydrogenation processes of ketones with chiral mol. catalysts are attracting increasing interest from synthetic chemists due to their operational simplicity. C2-sym. catalysts have also received much attention and been used in many reactions. A series of new chiral C2-sym. bis(phosphinite) ligands has been prepared from corresponding amino acid derived amino alcs. or (R)-2-amino-1-butanol through a three- or four-step procedure. Their structures have been elucidated by a combination of multinuclear NMR spectroscopy, IR spectroscopy and elemental anal. 1H-31P NMR, DEPT, 1H-13C HETCOR or 1H-1H COSY correlation experiments were used to confirm the spectral assignments. In situ prepared ruthenium catalytic systems were successfully applied to ruthenium-catalyzed asym. transfer hydrogenation of acetophenone derivatives by iso-PrOH. Under optimized conditions, these chiral ruthenium catalyst systems serve as catalyst precursors for the asym. transfer hydrogenation of acetophenone derivatives in iso-PrOH and act as good catalysts, giving the corresponding optical secondary alcs. in 99% yield and up to 79% ee. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3SDS of cas: 5856-63-3).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 5856-63-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts