Expedient approach for trans-esterification of β-keto esters under solvent free conditions using silica supported boric acid (SiO2-H3BO3) as a recyclable catalyst was written by Das, Kamal;Majumdar, Swapan. And the article was included in RSC Advances in 2022.Product Details of 2216-51-5 This article mentions the following:
A highly efficient trans-esterification of β-keto methyl/ethyl esters with primary, secondary, allylic, benzylic and chiral alcs. has been carried out in excellent yields under solvent-free conditions using silica supported boric acid as a heterogeneous catalyst. This sustainable protocol resulted in a remarkable enhancement in the synthetic efficiency (87-95% yield) with high purity and eliminating the use of an environmentally toxic solvent. The work up procedure is very simple and the catalyst has been successfully recovered and recycled. The present methodol. is also applicable for trans-esterification with chiral alcs. on a multi-gram scale without compromising the yield. Noteworthy features of this protocol are simple operational procedure, minimizing production of chem. waste, mild reaction conditions, easy preparation of the catalyst and its recyclability up to five cycles without any appreciable loss of catalytic activity. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Product Details of 2216-51-5).
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Product Details of 2216-51-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts