Nickel-Catalyzed Phosphine Free Direct N-Alkylation of Amides with Alcohols was written by Das, Jagadish;Banerjee, Debasis. And the article was included in Journal of Organic Chemistry in 2018.Electric Literature of C7H6Cl2O This article mentions the following:
Herein, we developed an operational simple, practical, and selective Ni-catalyzed synthesis of secondary amides. Application of renewable alcs., earth-abundant and nonprecious nickel catalyst facilitates the transformations, releasing water as byproduct. The catalytic system is tolerant to a variety of functional groups including nitrile, allylic ether, and alkene and could be extended to the synthesis of bis-amide, antiemetic drug Tigan, and dopamine D2 receptor antagonist Itopride. Preliminary mechanistic studies revealed the participation of a benzylic C-H bond in the rate-determining step. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Electric Literature of C7H6Cl2O).
(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C7H6Cl2O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts