Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit was written by Backes, Bradley J.;Longenecker, Kenton;Hamilton, Gregory L.;Stewart, Kent;Lai, Chunqiu;Kopecka, Hana;von Geldern, Thomas W.;Madar, David J.;Pei, Zhonghua;Lubben, Thomas H.;Zinker, Bradley A.;Tian, Zhenping;Ballaron, Stephen J.;Stashko, Michael A.;Mika, Amanda K.;Beno, David W. A.;Kempf-Grote, Anita J.;Black-Schaefer, Candace;Sham, Hing L.;Trevillyan, James M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.COA of Formula: C7H9NO This article mentions the following:
A series of pyrrolidine-constrained phenethylamines were developed as dipeptidyl peptidase IV (DPP4) inhibitors for the treatment of type 2 diabetes. The cyclohexene ring of lead-like screening hit was replaced with a pyrrolidine to enable parallel chem., and protein co-crystal structural data guided the optimization of N-substituents. Employing this strategy, a >400× improvement in potency over the initial hit was realized in rapid fashion. Optimized compounds are potent and selective inhibitors with excellent pharmacokinetic profiles. Compound I was efficacious in vivo, lowering blood glucose in ZDF rats that were allowed to feed freely on a mixed meal. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0COA of Formula: C7H9NO).
6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.COA of Formula: C7H9NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts