Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study was written by Abdo, Nour;Xia, Menghang;Brown, Chad C.;Kosyk, Oksana;Huang, Ruili;Sakamuru, Srilatha;Zhou, Yi-Hui;Jack, John R.;Gallins, Paul;Xia, Kai;Li, Yun;Chiu, Weihsueh A.;Motsinger-Reif, Alison A.;Austin, Christopher P.;Tice, Raymond R.;Rusyn, Ivan;Wright, Fred A.. And the article was included in Environmental Health Perspectives in 2015.Computed Properties of C10H14O5 This article mentions the following:
Background: Understanding of human variation in toxicity to environmental chems. remains limited, so human health risk assessments still largely rely on a generic 10-fold factor (101/2 each for toxicokinetics and toxicodynamics) to account for sensitive individuals or subpopulations. Objectives: We tested a hypothesis that population-wide in vitro cytotoxicity screening can rapidly inform both the magnitude of and mol. causes for interindividual toxicodynamic variability. Methods: We used 1086 lymphoblastoid cell lines from the 1000 Genomes Project, representing nine populations from five continents, to assess variation in cytotoxic response to 179 chems. Anal. included assessments of population variation and heritability, and genome-wide association mapping, with attention to phenotypic relevance to human exposures. Results: For about half the tested compounds, cytotoxic response in the 1% most “sensitive” individual occurred at concentrations within a factor of 101/2 (i.e., approx. 3) of that in the median individual; however, for some compounds, this factor was > 10. Genetic mapping suggested important roles for variation in membrane and transmembrane genes, with a number of chems. showing association with SNP rs13120371 in the solute carrier SLC7A11, previously implicated in chemoresistance. Conclusions: This exptl. approach fills critical gaps unaddressed by recent large-scale toxicity testing programs, providing quant., exptl. based estimates of human toxicodynamic variability, and also testable hypotheses about mechanisms contributing to interindividual variation. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Computed Properties of C10H14O5).
Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C10H14O5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts