A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates was written by Zhang, Penghui;Gao, Di;An, Keli;Shen, Qi;Wang, Chen;Zhang, Yuchao;Pan, Xiaoshu;Chen, Xigao;Lyv, Yifan;Cui, Cheng;Liang, Tingxizi;Duan, Xiaoman;Liu, Jie;Yang, Tielin;Hu, Xiaoxiao;Zhu, Jun-Jie;Xu, Feng;Tan, Weihong. And the article was included in Nature Chemistry in 2020.Recommanded Product: (3-Methyl-2-nitrophenyl)methanol This article mentions the following:
Abstract: Stimuli-responsive biomaterials that contain logic gates hold great potential for detecting and responding to pathol. markers as part of clin. therapies. However, a major barrier is the lack of a generalized system that can be used to easily assemble different ligand-responsive units to form programmable nanodevices for advanced biocomputation. Here we develop a programmable polymer library by including responsive units in building blocks with similar structure and reactivity. Using these polymers, we have developed a series of smart nanocarriers with hierarchical structures containing logic gates linked to self-immolative motifs. Designed with disease biomarkers as inputs, our logic devices showed site-specific release of multiple therapeutics (including kinase inhibitors, drugs and short interfering RNA) in vitro and in vivo. We expect that this ‘plug and play’ platform will be expanded towards smart biomaterial engineering for therapeutic delivery, precision medicine, tissue engineering and stem cell therapy. In the experiment, the researchers used many compounds, for example, (3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8Recommanded Product: (3-Methyl-2-nitrophenyl)methanol).
(3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: (3-Methyl-2-nitrophenyl)methanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts