Stereoinversion of 1-arylethanols by Cyanidioschyzon merolae NEIS-1332 was written by Utsukihara, Takamitsu;Misumi, Osami;Nakajima, Koichi;Koshimura, Masahiro;Kuniyoshi, Masayuki;Kuroiwa, Tsuneyoshi;Horiuchi, C. Akira. And the article was included in Journal of Molecular Catalysis B: Enzymatic in 2008.Synthetic Route of C8H9FO This article mentions the following:
The stereoinversion of 2-, 3-, and 4-RC6H4CHMeOH [I, R = F, Cl, Br, Me] using the red alga Cyanidioschyzon merolae was investigated. It was found that I [R = 4-Cl] gave the (S)-alc. in high ee and high yield (95%, 91% ee). On the other hand, stereoinversion of I [R = 3-Cl] occurred with moderate ee (54% ee). In the case of I [R = 2-Cl], the biotransformation did not proceed. PhCHR1OH [R1 = Me, Et, Pr, Bu] and cis-2-methylcyclohexanol were similarly subjected to stereoinversion. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Synthetic Route of C8H9FO).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C8H9FO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts