The effect of the high-fat diet supplemented with various forms of chromium on rats body composition, liver metabolism and organ histology Cr in liver metabolism and histology of selected organs was written by Ognik, Katarzyna;Dworzanski, Wojciech;Sembratowicz, Iwona;Fotschki, Bartosz;Cholewinska, Ewelina;Listos, Piotr;Juskiewicz, Jerzy. And the article was included in Journal of Trace Elements in Medicine and Biology in 2021.SDS of cas: 137-08-6 This article mentions the following:
In the present study, we hypothesized that feeding rats a high-fat diet neg. affects liver metabolism and function and disturbs the histol. of some internal organs. We also postulated that there is a form of chromium whose administration alleviates the neg. effects of a high-fat diet in rats. To verify the hypotheses, we tested the effect of various forms of chrome (picolinate – Cr-Pic, Chromium(III)-methionine complex – Cr-Met, and chrome nanoparticles – Cr-NPs) applied in the recommended amount of 0.3 mg/kg of BW on growth parameters, body fat, liver metabolism and functional disorders, and histol. parameters of selected internal organs in rats fed a standard (S) or high-fat diet (F). The experiment was conducted on 56 male outbred Wistar rats (Rattus norvegicus. Cmdb:WI) randomly divided into eight exptl. groups. For eight weeks the rats received a standard or high-fat diet, without Cr or with Cr at 0.3 mg/kg diet in the form of Cr-Pic, Cr-Met or Cr-NPs. The use of a F diet disrupted the lipid-carbohydrate profile, worsened liver metabolism and function, reduced the expression of hepatic PPAR-α and leaded to neg. changes in the histol. image of internal organs – liver, kidneys and pancreas. The 8-wk use of an chromium supplement in a F diet, regardless of the form used, did not improve the ratio of fat tissue to lean tissue, worsened liver function and neg. affected on the histol. image of the liver, kidneys and pancreas. However, the most neg. changes in lipid-carbohydrate metabolism and liver functioning were observed with CrNPs supplementation. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6SDS of cas: 137-08-6).
Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 137-08-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts