Ni, Tingjunhong et al. published their research in Molecules in 2022 | CAS: 5856-63-3

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Electric Literature of C4H11NO

Design, Synthesis, and In Vitro and In Vivo Antifungal Activity of Novel Triazoles Containing Phenylethynyl Pyrazole Side Chains was written by Ni, Tingjunhong;Ding, Zichao;Xie, Fei;Hao, Yumeng;Bao, Junhe;Zhang, Jingxiang;Yu, Shichong;Jiang, Yuanying;Zhang, Dazhi. And the article was included in Molecules in 2022.Electric Literature of C4H11NO This article mentions the following:

A series of triazole derivatives containing phenylethynyl pyrazole moiety as side chain I (R = 4-fluorobenzylaminyl, 4-hydroxypiperidin-1-yl, morpholin-4-yl, etc.) and II (R1 = F, Cl, CN, CF3, OCF3) were designed, synthesized, and most of them exhibited good in vitro antifungal activities. Especially, triazole derivatives I (R = (furan-2-ylmethyl)aminyl) and II (R1 = CN) showed excellent in vitro activities against C. albicans (MIC = 0.125, 0.0625μg/mL), C. neoformans (MIC = 0.125, 0.0625μg/mL), and A. fumigatus (MIC = 8.0, 4.0μg/mL). Triazole derivatives II (R1 = CN) also exerted superior activity to triazole derivatives I (R = (furan-2-ylmethyl)aminyl) and fluconazole in inhibiting hyphae growth of C. albicans and inhibiting drug-resistant strains of C. albicans, and it could reduce fungal burdens in mice kidney at a dosage of 1.0 mg/kg. An in vivo efficacy evaluation indicated that triazole derivatives II (R1 = CN) could effectively protect mice models from C. albicans infection at doses of 0.5, 1.0, and 2.0 mg/kg. These results suggested that triazole derivatives II (R1 = CN) deserves further investigation. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Electric Literature of C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Electric Literature of C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts