Synthesis of enantioenriched 2,2-disubstituted pyrrolidines via sequential asymmetric allylic alkylation and ring contraction was written by Goldstein, Elizabeth L.;Takada, Hirokazu;Sumii, Yuji;Baba, Katsuaki;Stoltz, Brian M.. And the article was included in Tetrahedron in 2022.Computed Properties of C3H8O2 This article mentions the following:
The synthesis of a variety of enantioenriched 2,2-disubstituted pyrrolidines I (R = Bn, t-Bu; R1 = CH3, CH2CH3, CH2C6H5, (CH2)2CF3) is described. A stereogenic quaternary center is first formed utilizing an asym. allylic alkylation reaction of benzyloxy imides II, which can then be reduced to chiral hydroxamic acids III. This compound can then undergo a thermal ‘Spino’ ring contraction to afford carbamate protected 2,2-disubstituted pyrrolidines I stereospecifically. These pyrrolidines I can be further advanced to enantioenriched indolizidine compds like (8aS)-6-(3,4-dimethoxyphenyl)-8a-methyl-1,2,3,5,8,8a-hexahydroindolizine. This reaction sequence allows access to new mols. that could be useful in the development of pharmaceutical agents. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Computed Properties of C3H8O2).
1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Computed Properties of C3H8O2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts