Directed β C-H Amination of Alcohols via Radical Relay Chaperones was written by Wappes, Ethan A.;Nakafuku, Kohki M.;Nagib, David A.. And the article was included in Journal of the American Chemical Society in 2017.Application of 94022-96-5 This article mentions the following:
A radical-mediated strategy for β C-H amination of alcs. has been developed. This approach employs a radical relay chaperone, which serves as a traceless director that facilitates selective C-H functionalization via 1,5-hydrogen atom transfer (HAT) and enables net incorporation of ammonia at the β carbon of alcs. The chaperones presented herein enable direct access to imidate radicals, allowing their first use for H atom abstraction. A streamlined protocol enables rapid conversion of alcs. to their β-amino analogs (via in situ conversion of alcs. to imidates, directed C-H amination, and hydrolysis to NH2). Mechanistic experiments indicate HAT is rate-limiting, whereas intramol. amination is product- and stereo-determining In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Application of 94022-96-5).
2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 94022-96-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts