Synthesis of potent and highly selective inhibitors of human tryptase was written by Slusarchyk, William A.;Bolton, Scott A.;Hartl, Karen S.;Huang, Ming-Hsing;Jacobs, Glenn;Meng, Wei;Ogletree, Martin L.;Pi, Zulan;Schumacher, William A.;Seiler, Steven M.;Sutton, James C.;Treuner, Uwe;Zahler, Robert;Zhao, Guohua;Bisacchi, Gregory S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.SDS of cas: 142253-56-3 This article mentions the following:
The serine protease tryptase is implicated in allergic and inflammatory diseases and associated with asthma. The synthesis and SAR of a series of N1-activated-4-carboxy azetidinones are described, resulting in identification of BMS-363131 (I) as a potent inhibitor of human tryptase (IC50<1.7 nM) with high selectivity (>3000-fold) for tryptase vs. related serine proteases including trypsin. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3SDS of cas: 142253-56-3).
1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 142253-56-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts