On the interactions of diols and DMPC monolayers was written by Rhys, Natasha H.;Barlow, David J.;Lawrence, M. Jayne;Lorenz, Christian D.. And the article was included in Journal of Molecular Liquids in 2022.Safety of 1,2-Propanediol This article mentions the following:
The interactions of lipid mols. with various solvent mols. is of utmost importance in the formulation of various drug delivery and personal care formulations. In this manuscript, a series of all-atom mol. dynamics simulations were used to investigate how the structural and interfacial properties of a DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) monolayer change when interacting with a range of diols that have varying carbon chain lengths and patterns of hydroxylation. In comparison to water, we find that all of the diols studied result in a more disordered and thinner monolayer. Addnl., we find that the shorter diols with the hydroxyl groups on neighboring carbons (1,2-ethanediol and 1,2-propanediol) are able to penetrate deeper into the head group region of the lipid monolayers and as a result significantly disorder and thin the monolayers. Like water, we find that the diols also form hydrogen-bonded networks that connect the DMPC head groups in neighboring mols. Interestingly, we find that the number of butanediol mols. that form these solvent-mediated interactions between the DMPC head groups is directly affected by the distribution of the hydroxyl groups within the diol mols. The results presented here provide a mechanistic description of how the chem. of diol solvent mols. will affect the structural and interfacial properties of lipid structures in solution In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Safety of 1,2-Propanediol).
1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of 1,2-Propanediol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts