Tunable, responsive nanogels containing t-butyl methacrylate and 2-(t-butylamino)ethyl methacrylate was written by Liechty, William B.;Scheuerle, Rebekah L.;Peppas, Nicholas A.. And the article was included in Polymer in 2013.Name: ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:
We present the synthesis and characterization of a series of pH-responsive hydrogel nanoparticles based on crosslinked 2-(diethylaminoethyl) methacrylate and poly(ethylene glycol) Me ether methacrylate (P(DEAEMA-g-PEGMA)). Variants of this polymer were created using t-Bu methacrylate (P(DEAEMA-co-TBMA-g-PEGMA)) or t-butylaminoethyl methacrylate (P(DEAEMA-co-TBAEMA-g-PEGMA)). The synthesis of these materials was accomplished using a facile photoemulsion polymerization Polymer composition was verified using 1H NMR spectroscopy and closely approximates the copolymer composition estimated from reactivity ratios. Particle formulations possess a dry diameter of 50-65 nm as determined by transmission electron microscopy and collapsed hydrodynamic diameter of 70-100 nm as determined by dynamic light scattering. Dynamic light scattering and pyrene fluorescence spectroscopy were used to probe the pH-dependent phase transition in the hydrogel nanoparticles from collapsed hydrophobe to swollen hydrophile. The inclusion of t-Bu methacrylate served to depress the nanogel pKa and critical pH for phase transition to <6.9 while the inclusion of t-butylamino methacrylate had the opposite effect. We show that these hydrogel nanoparticles possess tunable physicochem. properties that can be adjusted by changing copolymer composition In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Name: ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).
((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)
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