Employing Abraham and Hansen Parameters for Solubility Prediction of Ketoconazole in Binary Solvents at Various Temperatures was written by Karimzadeh, Zahra;Rahimpour, Elaheh;Acree, William E. Jr.;Jouyban, Abolghasem. And the article was included in Journal of Solution Chemistry in 2022.Application of 57-55-6 This article mentions the following:
The Jouyban-Acree model is reported to be the most accurate math. model for predicting drug solubility in the mixed solvents at various temperatures In this study, the solubility of ketoconazole is predicted using the Jouyban-Acree based general models in some previously reported co-solvency systems. For this purpose, parameters of the Hansen solubility and the Abraham solvation parameters are combined with the Jouyban-Acree model and are trained with reported solubility data for ketoconazole to reach predictive co-solvency models. For investigation of the models’ accuracies, the values for mean relative deviations of predicted data from published exptl. values are calculated and discussed. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Application of 57-55-6).
1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 57-55-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts